Correlation Between Serum Copper and Cardiac Enzymes in Acute Myocardial Infarction

Last updated: July 12, 2025
Sponsor: Sohag University
Overall Status: Completed

Phase

N/A

Condition

Cardiac Disease

Blood Clots

Heart Disease

Treatment

Transthoracic echocardiography

Clinical Study ID

NCT07076758
Soh-Med-25-5-7PD
  • Ages > 18
  • All Genders

Study Summary

This study aims to investigate the correlation between serum copper levels and cardiac enzymes in patients with acute myocardial infarction (AMI).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥18 years old.

  • Both sexes.

  • Patients with acute myocardial infarction (AMI). AMI are defined as patientscomplaining of typical continuous chest pain for more than 30 min: ST-segmentelevation of more than 0.1 mV in two or more successive leads or ST-segmentdepression of more than 0.1 mV in two or more successive leads monitored by astandard 12-lead ECG and rise of either creatine kinase (CK) or MB fraction ofcreatine kinase (CKMB) to greater than twice the normal level or elevation oftroponin I [cardiac troponin T (cTnT)] more than or equal to 0.1 ng/ml

Exclusion

Exclusion Criteria:

  • Patients with insufficient clinical information.

  • Passed time MI (if patients presented with symptoms that lasted >24 h).

  • Cardiogenic shock.

  • Chronic kidney disease.

  • Chronic liver cell failure.

  • Significant valvular heart disease.

  • Hematological disease.

  • Malignancy.

  • Severe liver or renal disease.

  • Systemic inflammatory disease.

  • Active infection.

  • Autoimmune disease.

  • Patients on steroids whatever the cause is.

Study Design

Total Participants: 70
Treatment Group(s): 1
Primary Treatment: Transthoracic echocardiography
Phase:
Study Start date:
January 01, 2025
Estimated Completion Date:
July 08, 2025

Study Description

Acute myocardial infarction (AMI) is one of the most serious types of coronary artery disease (CAD). In CAD, coronary blood flow is drastically reduced or interrupted, causing severe myocardial ischemia or necrosis.

Cardiac troponin I (TNI), creatine kinase (CK), and creatine kinase MB (CK-MB) are the most commonly used biomarkers for AMI clinical diagnosis. Among them, cardiac troponin is a highly specific biomarker for the diagnosis of AMI. However, the sensitivity is not good in the first few AMI hours, and false-positive values may occur in severe heart failure, arrhythmia, and myocarditis.

Copper is vital in multiple enzymes necessary for antioxidant protection, such as Superoxide dismutases (SOD) and ceruloplasmin. SOD is an enzyme that changes superoxide radicals into hydrogen peroxide, whereas ceruloplasmin is an antioxidant protein that aids in eliminating free radicals.

Connect with a study center

  • Sohag University

    Sohag, 82511
    Egypt

    Site Not Available

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