General Anesthesia Versus Spinal Anesthesia With Local Anesthetic Infiltration for Buccal Mucosal Graft in Urethroplasty

Last updated: July 19, 2025
Sponsor: Tanta University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Anesthesia (Local)

Anesthesia

Treatment

Spinal anesthesia

General anesthesia

Clinical Study ID

NCT07074730
36265MD360/1/25
  • Ages > 21
  • Male

Study Summary

This study aims to compare general anesthesia and spinal anesthesia with local anesthetic infiltration for buccal mucosal graft (BMG) in urethroplasty.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male patient age ≥ 21 years.

  • American Society of Anesthesiologists (ASA) classification I-II.

  • Patient scheduled for urethroplasty.

Exclusion

Exclusion Criteria:

  • Patients who are taking analgesics for chronic illness or have a history ofsubstance abuse.

  • Patients who are unable to describe their postoperative pain (e.g., neuropsychiatricdisorder).

  • Patients with known local anesthetics and opioid allergy.

  • Patients with infection at the site of the needle puncture.

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Spinal anesthesia
Phase:
Study Start date:
July 19, 2025
Estimated Completion Date:
March 01, 2027

Study Description

Urethroplasty is a surgical procedure aimed at reconstructing the urethra and is considered the standard treatment for bulbar urethral strictures, with different types of tissues used as either grafts or flaps, affecting approximately 300 per 100,000 males.

Postoperative pain following urethroplasty with buccal mucosal graft (BMG) is primarily related to the oral graft harvest site.

General Anesthesia provides a state of complete unconsciousness, ensuring that patients are free from pain and awareness during the surgery. It can be beneficial in complex cases or when extended manipulation is required, allowing for muscle relaxation and controlled ventilation.

On the other hand, spinal anesthesia involves the injection of anesthesia into the cerebrospinal fluid, resulting in targeted numbness in the lower body. This technique can be advantageous for its fast, simple, cost-effective method, rapid onset, lower risk of systemic complications, and preservation of airway reflexes.

Connect with a study center

  • Tanta University

    Tanta, El-Gharbia 31527
    Egypt

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.