A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

Last updated: May 18, 2026
Sponsor: Pfizer
Overall Status: Active - Recruiting

Phase

2

Condition

Cardiovascular Disease

Williams Syndrome

Heart Disease

Treatment

PF-07868489

Clinical Study ID

NCT07073820
C5001004
2025-521155-23-00
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to learn about the long-term safety, tolerability and effects of the study medicine (PF-07868489) for the possible treatment of PAH. PAH is a condition in which there is high blood pressure in the arteries that carry blood from the heart to the lungs. This high pressure makes it harder for the heart to pump blood through those lungs, potentially damaging the right side of the heart.

This is an open-label study. Which means that both the healthcare providers and the study participants are aware of the medicine being given. This study is also an extension study with study medicine (PF-07868489). An extension study allows patients from an earlier clinical study (also called as qualifying study) to continue participating to assess long-term benefits and safety of the medicine.

Eligibility Criteria

Inclusion

This study is seeking participants who are:

  • aged 18 years or older at screening of the previous study and completed the required treatment duration with PF-07868469 and other assessments at the end of that study.

  • willing and able to abide with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures.

  • do not have worsening or hospitalization for worsening PAH during the qualifying study.

  • not on placement for a surgery to replace any tissue or part of the body (transplant), and planned surgery for PAH.

  • do not have an ongoing major health issue in the qualifying study, which in the opinion of the study doctor could make the participant not qualify for this study.

  • not suffering from or in the past have suffered from hepato-pulmonary syndrome (liver-related lung problem).

  • not currently prescribed or taking medicines called as GLP-1 agonist.

Study Design

Total Participants: 36
Treatment Group(s): 1
Primary Treatment: PF-07868489
Phase: 2
Study Start date:
November 10, 2025
Estimated Completion Date:
July 18, 2028

Connect with a study center

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales 2050
    Australia

    Active - Recruiting

  • Royal Prince Alfred Hospital

    Camperdown 2172563, New South Wales 2155400 2050
    Australia

    Site Not Available

  • Pulmonary Hypertension Research Queensland Pty Ltd

    Auchenflower, Queensland 4066
    Australia

    Active - Recruiting

  • HUB Hôpital Erasme

    Brussels, 1070
    Belgium

    Active - Recruiting

  • UZ Leuven

    Leuven, 3000
    Belgium

    Active - Recruiting

  • London Health Sciences Centre

    London, Ontario N6A 5W9
    Canada

    Site Not Available

  • London Health Sciences Centre - University Hospital

    London, Ontario N6A 5A5
    Canada

    Site Not Available

  • London Health Sciences Centre

    London 6058560, Ontario 6093943 N6A 5W9
    Canada

    Site Not Available

  • London Health Sciences Centre - University Hospital

    London 6058560, Ontario 6093943 N6A 5A5
    Canada

    Site Not Available

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong 510080
    China

    Active - Recruiting

  • Guangdong Provincial People's Hospital

    Guangzhou 1809858, Guangdong 1809935 510080
    China

    Site Not Available

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan 410011
    China

    Active - Recruiting

  • Zhongda Hospital Southeast University

    Nanjing, Jiangsu 210009
    China

    Active - Recruiting

  • Shanghai Pulmonary Hospital

    Shanghai, Shanghai Municipality 200433
    China

    Active - Recruiting

  • Vseobecna fakultni nemocnice v Praze

    Prague, 12808
    Czechia

    Active - Recruiting

  • CHRU de Brest

    Brest, Finistère 29200
    France

    Active - Recruiting

  • Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord

    Saint Priest En Jarez, Pays de la Loire Region 42270
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Saint-Etienne, Hôpital Nord

    Saint-Priest-en-Jarez, 42055
    France

    Active - Recruiting

  • Thoraxklinik-Heidelberg gGmbH

    Heidelberg, Baden-Wurttemberg 69126
    Germany

    Active - Recruiting

  • Thoraxklinik-Heidelberg gGmbH

    Heidelberg 2907911, Baden-Wurttemberg 2953481 69126
    Germany

    Site Not Available

  • Universitätsklinikum Regensburg

    Regensburg, Bavaria 93053
    Germany

    Active - Recruiting

  • Universitätsklinikum Regensburg

    Regensburg 2849483, Bavaria 2951839 93053
    Germany

    Site Not Available

  • Universitaetsklinikum Giessen und Marburg GmbH

    Giessen, Hesse 35392
    Germany

    Active - Recruiting

  • Universitaetsklinikum Giessen und Marburg GmbH

    Giessen 2920512, Hesse 2905330 35392
    Germany

    Site Not Available

  • Universitätsmedizin Greifswald

    Greifswald, Mecklenburg-Vorpommern 17475
    Germany

    Active - Recruiting

  • Universitätsmedizin Greifswald

    Greifswald 2917788, Mecklenburg-Vorpommern 2872567 17475
    Germany

    Site Not Available

  • Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden

    Dresden, Saxony 01307
    Germany

    Active - Recruiting

  • Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden

    Dresden 2935022, Saxony 2842566 01307
    Germany

    Site Not Available

  • University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA"

    Chaïdári, Attica 12461
    Greece

    Active - Recruiting

  • Onassis Hospital

    Kallithea, Attica 17674
    Greece

    Site Not Available

  • AHEPA University General Hospital of Thessaloniki

    Thessaloniki, Central Macedonia 54636
    Greece

    Active - Recruiting

  • Fondazione IRCCS San Gerardo dei Tintori

    Monza, Monza E Brianza 20900
    Italy

    Site Not Available

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100
    Italy

    Active - Recruiting

  • Kobe University Hospital

    Kobe, Hyōgo 650-0017
    Japan

    Active - Recruiting

  • Kobe University Hospital

    Kobe 1859171, Hyōgo 1862047 650-0017
    Japan

    Site Not Available

  • St. Marianna University Hospital

    Kawasaki, Kanagawa 216-8511
    Japan

    Active - Recruiting

  • St. Marianna University Hospital

    Kawasaki 1859642, Kanagawa 1860291 216-8511
    Japan

    Site Not Available

  • Tohoku University Hospital

    Sendai, Miyagi 980-8574
    Japan

    Site Not Available

  • Tohoku University Hospital

    Sendai 2111149, Miyagi 2111888 980-8574
    Japan

    Site Not Available

  • National Hospital Organization Okayama Medical Center

    Okayama, 701-1192
    Japan

    Active - Recruiting

  • National Hospital Organization Okayama Medical Center

    Okayama 1854383, 701-1192
    Japan

    Site Not Available

  • Gachon University Gil Medical Center

    Incheon, Incheon-gwangyeoksi [incheon] 21565
    South Korea

    Active - Recruiting

  • Gachon University Gil Medical Center

    Incheon 1843564, Incheon-gwangyeoksi [incheon] 21565
    South Korea

    Site Not Available

  • Samsung Medical Center

    Seoul, Seoul-teukbyeolsi [seoul] 06351
    South Korea

    Active - Recruiting

  • Seoul National University Hospital

    Seoul, Seoul-teukbyeolsi [seoul] 03080
    South Korea

    Active - Recruiting

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul-teukbyeolsi [seoul] 03722
    South Korea

    Active - Recruiting

  • Samsung Medical Center

    Seoul 1835848, Seoul-teukbyeolsi [seoul] 06351
    South Korea

    Site Not Available

  • Seoul National University Hospital

    Seoul 1835848, Seoul-teukbyeolsi [seoul] 03080
    South Korea

    Active - Recruiting

  • Severance Hospital, Yonsei University Health System

    Seoul 1835848, Seoul-teukbyeolsi [seoul] 03722
    South Korea

    Active - Recruiting

  • Hospital Universitario Marques de Valdecilla

    Santander, Cantabria 39008
    Spain

    Active - Recruiting

  • Hospital Universitario Marques de Valdecilla

    Santander 3109718, Cantabria 3336898 39008
    Spain

    Site Not Available

  • Hospital Universitario La Paz

    Madrid, Madrid, Comunidad de 28046
    Spain

    Active - Recruiting

  • Hospital Universitario La Paz

    Madrid 3117735, Madrid, Comunidad de 28046
    Spain

    Site Not Available

  • Hospital Universitario 12 de Octubre

    Madrid, 28041
    Spain

    Active - Recruiting

  • Hospital Universitario 12 de Octubre

    Madrid 3117735, 28041
    Spain

    Site Not Available

  • Hammersmith Hospital

    London, Greater London W12 0HS
    United Kingdom

    Active - Recruiting

  • Hammersmith Hospital

    London 2643743, Greater London W12 0HS
    United Kingdom

    Site Not Available

  • UC Davis Health Medical Center

    Sacramento, California 95817
    United States

    Site Not Available

  • Heart and Vascular Center

    San Francisco, California 94143
    United States

    Active - Recruiting

  • UCSF Health St. Mary's Hospital

    San Francisco, California 94117
    United States

    Active - Recruiting

  • Heart and Vascular Center

    San Francisco 5391959, California 5332921 94143
    United States

    Site Not Available

  • UCSF Health St. Mary's Hospital

    San Francisco 5391959, California 5332921 94117
    United States

    Site Not Available

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado 80045
    United States

    Active - Recruiting

  • University of Colorado Anschutz Medical Campus

    Aurora 5412347, Colorado 5417618 80045
    United States

    Site Not Available

  • Norton Hospital

    Louisville, Kentucky 40202
    United States

    Active - Recruiting

  • Norton Pulmonary Specialists

    Louisville, Kentucky 40202
    United States

    Active - Recruiting

  • Norton Hospital

    Louisville 4299276, Kentucky 6254925 40202
    United States

    Active - Recruiting

  • Norton Pulmonary Specialists

    Louisville 4299276, Kentucky 6254925 40202
    United States

    Site Not Available

  • Mount Sinai Hospital

    New York, New York 10029
    United States

    Site Not Available

  • Clinical Trials Unit at Eastowne Medical Office Building

    Chapel Hill, North Carolina 27514
    United States

    Active - Recruiting

  • Pulmonary Hypertension Clinical Trials Office at Eastowne

    Chapel Hill, North Carolina 27514
    United States

    Active - Recruiting

  • Pulmonary Specialty Clinic at Eastowne Medical Office Building

    Chapel Hill, North Carolina 27514
    United States

    Active - Recruiting

  • UNC Hospitals

    Chapel Hill, North Carolina 27514
    United States

    Active - Recruiting

  • Center for Advanced Lung Care

    Providence, Rhode Island 02904
    United States

    Active - Recruiting

  • Rhode Island Hospital

    Providence, Rhode Island 02903
    United States

    Active - Recruiting

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