Cough Management Wellness App for Refractory or Unexplained Chronic Cough

Inclusion Criteria:

• Age 21 or older.

• Currently suffering from a cough that started at least 8 weeks ago that is largelyunproductive (i.e., at least 50% of the time the cough produces zero mucus thatneeds to be spit out or swallowed).

• Normal chest X-ray or chest CT scan at some point that was prescribed specificallyfor their cough.

• At least one physician visit for cough with standard-of-care therapy but inadequatesymptom relief.

• Stability of treatment: willing to avoid new cough treatments during study or reportchanges if they occur.

• Ability to comply: willing/able to wear the watch daily for the required duration ofstudy and to complete all required questionnaires.

• Informed consent: understanding of the study procedures and agreement to comply withprotocol.

Exclusion Criteria:

• Recent upper respiratory infection (past 4 weeks).

• History of hemoptysis (coughing up blood) since onset of the current cough.

• Current smoker (incl. vaping) of any substance.

• ≥10 consecutive pack-years smoking history within <10 years prior to screening.

• Diagnosed with a chronic lung condition (COPD, emphysema, lung cancer, IPF, chronicbronchitis, asthma). Note: Suspected asthma without confirmed diagnosis or benefitfrom asthma therapy is not an exclusion.

• Current or past head/neck cancer.

• Difficulty swallowing.

• On ACE inhibitors, such as Benzapril (Lotensin), Captopril (Capoten),Enalapril/Enalaprilat (Vasotec oral and injectable), Fosinopril (Monopril),Lisinopril (Zestril and Prinivil), Moexipril (Univasc), Perindopril (Aceon),Quinapril (Accupril), Ramipril (Altace), and Trandolapril (Mavik)

• Prior treatment for cough by a speech-language pathologist.

• Living with another individual with a frequent cough that would interfere withmonitoring.

• Participation in any cough intervention study within 30 days or 5 half-lives of theintervention.

• Major scheduled surgery during the study period.