Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

Last updated: July 2, 2025
Sponsor: McMaster University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Placebo

Ketone Monoester (KME)

Clinical Study ID

NCT07063732
KETEX_WM
  • Ages 18-35
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Must be a member of the research expedition team travelling to the Barcroft ResearchStation in White Mountain California

Exclusion

Exclusion Criteria:

  • BMI > 30

  • No prescribed medications (oral contraceptives excluded)

  • History of smoking

  • Currently following a ketogenic diet or consuming exogenous ketogenic supplements

  • History of heart, lung, blood vessel, or kidney disease

  • Currently pregnant

Study Design

Total Participants: 14
Treatment Group(s): 2
Primary Treatment: Placebo
Phase:
Study Start date:
May 28, 2025
Estimated Completion Date:
August 31, 2025

Connect with a study center

  • University of Guelph

    Guelph, Ontario N1G 2W1
    Canada

    Active - Recruiting

  • Barcroft Research Station

    Bishop, California 93514
    United States

    Active - Recruiting

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