Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)

Phase

N/A

Condition

Pregnancy

Post-traumatic Stress Disorders

Treatment

Regular CPT

Massed CPT

Clinical Study ID

NCT07060144

00006641

Ages 18-46
Female

Study Summary

Pregnant women with a primary diagnosis of posttraumatic stress disorder (PTSD) (PTSD Checklist for DSM-5 (PCL-5) score > 33) will be randomized to receive conventional cognitive processing therapy (CPT) (60-min session once/week for 12 weeks) or massed CPT (mCPT) (an intensive schedule of 12 60-min sessions over 5 days, approximately 2-3 sessions per day) via telemedicine, for treatment of PTSD. The research aims will be three-fold: (1) Evaluate the relative efficacy and tolerability of CPT vs. mCPT for treatment of perinatal PTSD and depression; (2) Determine the effect of CPT upon maternal-infant attachment and interaction; (3) Collect pilot data of obstetric and neonatal outcomes among those receiving the two CPT delivery schedules.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Female, ages 18-46, Pregnant (< 25 weeks), able to read and write in English,History of at least 1 criterion A trauma, Primary diagnosis of PTSD (confirmed bySCID), Psychotropic medications must be stable with no changes ≥ 2 weeks (≥ 6 weeksfor fluoxetine), and no medication changes can be made during the course of therapy

Exclusion

Exclusion Criteria:

Not currently pregnant, Diagnosis of bipolar disorder, psychotic disorders, Suicidalideation with plan or intent, Substance use disorder, Regular benzodiazepine use (> 4x weekly)

Study Design

Regular CPT

August 01, 2025

October 31, 2027

Connect with a study center

University of Texas at Austin, Dell Medical School, Department of Psychiatry
Austin, Texas 78701
United States
Active - Recruiting

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