Distance-Based Exercise to Preserve Function and Prevent Disability

Inclusion Criteria:

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Participants must have histologicallyconfirmed cancer

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Participants must be initiatingoutpatient cytotoxic chemotherapy for curative intent (for any malignancy) of atleast 10 weeks duration (with or without concurrent radiation, immunotherapy, orother targeted therapy). Patients must be enrolled and baseline measures collectedon or before administration of their second cycle of cytotoxic therapy. Patientsreceiving outpatient cytotoxic chemotherapy for curative intent in the neoadjuvantor adjuvant setting for solid tumors are eligible. Patients receiving outpatientcytotoxic chemotherapy given for curative intent for hematologic malignancies, aswell as patients receiving definitive chemoradiation for solid tumors, are alsoeligible. Regimens of immunotherapy or monoclonal antibodies ONLY are not eligible

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Age 18-64 years

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients cannot have metastatic cancer

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients cannot have documentation inthe medical record of severe cardiovascular, respiratory or musculoskeletal diseaseor joint problems that preclude moderate physical activity. Examples would includeunstable angina, recent myocardial infarction, oxygen-dependent pulmonary disease,and osteoarthritis requiring imminent joint replacement. Moderate arthritis thatdoes not preclude physical activity is not a reason for ineligibility

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients cannot be pregnant, becausethis study involves remotely delivered exercise, and cannot be breast-feeding aspatients must be receiving cytotoxic chemotherapy, during which breast-feeding iscontraindicated

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients cannot have documentation inthe medical record of current alcohol or substance abuse

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Engaged in full time gainful employmentof at least 30 hours per week at the time of cancer diagnosis

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Currently no self-report of engagementin competitive sports (e.g. not training for running races, triathlons, etc) AND noself-report of twice weekly progressive resistance exercise training within the pastyear

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Self-reported ability to walk for 6minutes (use of assistive devices will be allowed)

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Not participating in another weightloss, physical activity, or dietary intervention clinical trial

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Predicted 6MWT distance of 450 meters orless

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Concurrent enrollment in treatment orsupportive care trials (other than those focused on weight loss or exercise) isallowed with the permission of the Alliance Executive Officer and both studies'study chairs

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Eligibility is restricted to individualswho can comprehend and read English given that participation in the study willrequire the ability to read intervention materials and work with a coach throughtelehealth sessions

• REGISTRATION ELIGIBILITY CRITERIA (STEP 1): The trial is unable to accommodate theneeds of deaf or blind participants as the study relies on language andvisualization of exercise through telehealth sessions

• CLINICAL STAKEHOLDER ELIGIBILITY CRITERIA: Clinicians and research staff fromenrolling sites who meet following criterion will be deemed eligible to participateas a clinical stakeholder:

• Providing clinical care for participating patients on this study

• CLINICAL STAKEHOLDER ELIGIBILITY CRITERIA: Ability to speak and understand English

Exclusion Criteria: