The Effect of Pulsed Electromagnetic Field Therapy on Muscle Mass and Muscle Strength in Prostate Cancer Patients Treated With Androgen Deprivation Therapy

Last updated: July 4, 2025
Sponsor: Chinese University of Hong Kong
Overall Status: Active - Recruiting

Phase

N/A

Condition

Prostate Cancer

Prostate Cancer, Early, Recurrent

Urologic Cancer

Treatment

Pulsed electromagnetic fields Thearpy

Sham Therapy

Clinical Study ID

NCT07057375
CRE-2024.600-T
  • Ages > 18
  • Male

Study Summary

This study is to assess the effect of Pulsed electromagnetic fields (PEMF) on improving muscle mass and strength in prostate cancer patients with ADT.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients with age greater than or equal to 18 years old.

  • Histologically documented PCa

  • No evidence of distant metastasis (M1 disease)

  • With ADT exposure from six months to three years

  • Expected to continue for at least six months

  • At least four weeks after radical prostatectomy or completed radiotherapy

Exclusion

Exclusion Criteria:

  • Patients are still under active treatment, such as radiotherapy

  • Patients who are unable to walk for 400 m or undertake exercise that will affect theclinical assessment of muscle strength

  • Patients with amputated lower limbs or other body deformities that will affect thetreatment protocol

Study Design

Total Participants: 110
Treatment Group(s): 2
Primary Treatment: Pulsed electromagnetic fields Thearpy
Phase:
Study Start date:
June 01, 2025
Estimated Completion Date:
March 31, 2027

Study Description

This randomised parallel-group study assesses the efficacy, safety and tolerability of Pulsed electromagnetic fields (PEMF) on the muscle mass and strength in PCa patients treated with ADT.Treatment will be delivered using the BIXEPS system (QuantumTX, Singapore). During each treatment, the subject's quadriceps (thigh) region will be put into the machine and treated for 10 minutes for each lower limbs. The whole treatment consists of 1 therapy session per week for 12 weeks. The two lower limbs will be treated alternatively during the treatment. A set of assessments, including body composition assessment, muscle function assessment, questionnaire assessment, and blood and urine for inflammation and cytokines measurement, will be performed at baseline before the start of the first treatment, week 5 and week 12.

Connect with a study center

  • Prince of Wales Hospital

    Sha Tin,
    Hong Kong

    Active - Recruiting

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