Evidence-Based Nursing for Fatigue and Quality of Life in Lung Cancer Chemotherapy

Phase

N/A

Condition

Pain (Pediatric)

Lung Cancer

Cancer

Treatment

Routine Nursing Care

Evidence-Based Nursing Under Quantitative Assessment Strategy (EB-NQAS)

Clinical Study ID

NCT07049237

2023S00501

All Genders

Study Summary

This prospective randomized controlled trial investigated the effects of an evidence-based nursing intervention under a quantitative assessment strategy (EB-NQAS), utilizing the Edmonton Symptom Assessment Scale (ESAS), on cancer-related fatigue, self-management ability, and quality of life in lung cancer patients undergoing chemotherapy. Outcomes were compared to a group receiving routine nursing care.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Pathologically or radiologically confirmed lung cancer (World Health Organization [WHO] 2021 diagnostic criteria).
Scheduled to receive first-line chemotherapy (platinum-based regimen).
Karnofsky Performance Status (KPS) score ≥60.
Estimated survival time >6 months (assessed by treating oncologist).
Normal mental and cognitive function (Mini-Mental State Examination [MMSE] score ≥24).
Voluntary participation and signed informed consent.

Exclusion

Exclusion Criteria:

Concurrent severe organ dysfunction (Child-Pugh score ≥B for liver; estimatedglomerular filtration rate [eGFR] <30 mL/min/1.73m² for kidney).
Active neurological disorders (e.g., stroke, epilepsy) affecting symptom reporting.
Acute infectious diseases (e.g., tuberculosis with sputum positivity).
Known allergies to chemotherapy drugs (e.g., platinum agents).
Acute illnesses requiring hospitalization (e.g., pneumonia, myocardial infarction).
Secondary malignancies (pathologically confirmed).
Chemotherapy contraindications (e.g., uncontrolled heart failure).
Inability to communicate in the local language (assessed via nurse interview).
Concurrent radiotherapy or immunotherapy.
Participation in other interventional clinical trials within 3 months.

Study Design

Routine Nursing Care

January 01, 2024

January 01, 2025

Study Description

Lung cancer patients undergoing chemotherapy frequently experience significant cancer-related fatigue (CRF) and diminished quality of life (QoL), which may not be adequately addressed by conventional nursing approaches. This study aimed to evaluate the efficacy of an evidence-based nursing intervention guided by a quantitative assessment strategy (EB-NQAS). The EB-NQAS group (n=75) received personalized care plans developed by a dedicated nursing team. These plans were based on quantitative symptom assessment using the Edmonton Symptom Assessment Scale (ESAS) and incorporated evidence-based interventions for pain management (e.g., graded approach, music therapy, opioids), fatigue (e.g., activity plans, sleep optimization), nausea/vomiting prevention (e.g., prophylactic antiemetics, ginger, dietary advice), and psychological support (e.g., cognitive-behavioral therapy). Care plans were dynamically evaluated and adjusted based on daily and weekly ESAS monitoring. The control group (n=75) received routine nursing care, including standard health education, psychological support, dietary guidance, and adverse effect management. The study compared the effects of EB-NQAS versus routine nursing on CRF, self-management ability, QoL, and adverse events over a 3-month intervention period in 150 randomized lung cancer patients.

Connect with a study center

The First Hospital of Hebei Medical University
Shijiazhuang, Hebei 050000
China
Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.