Pretreatment of Acute Coronary Syndrome With Dual Antiplatelet Agents

Last updated: November 26, 2025
Sponsor: Jordan Collaborating Cardiology Group
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Disease

Myocardial Ischemia

Coronary Artery Disease

Treatment

N/A

Clinical Study ID

NCT07039149
DATES.2.25/irbIH1725
  • Ages > 18
  • All Genders

Study Summary

This is a chart review of data on use of antiplatelet (AP) medications for acute coronary syndrome in the ER. Guidelines recommend giving aspirin in the ER and a second AP agent in the cath lab. What is the outcome when the 2 agents are given n the ER?

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients

  • Presenting with acute coronary syndrome (ST segment elevation myocardial infarction,non ST segment elevation myocardial infarction, and unstable angina).

  • Antiplatelet medication (s) prescribed during index admission to hospital.

  • Willingness of the patient to be called for follow up up to 1 year after indexhospitalization.

Exclusion

Exclusion Criteria:

  • Non cardiac chest pain.

  • No administration of antiplatelet agents during hospitalization.

  • Refusal of contact for follow up.

Study Design

Total Participants: 200
Study Start date:
August 01, 2025
Estimated Completion Date:
November 01, 2026

Study Description

Dual antiplatelet therapy (DAPT) is a standard treatment in ST-elevation myocardial infarction (STEMI) and non-ST-segment-elevation acute coronary syndrome (NSTEACS) . However, the timing of initiation of DAPT in the Emergency Department (ED) has been defined by recent western guidelines (i.e., aspirin in the ER and and a second AP agent when the coronary anatomy has been denied in the cath lab. This strategy aims at decreasing the incidence of bleeding events. However, patients with ACS in the Middle East are younger than those in the West and have lower bleeding risk. The purpose of this study is to evaluate the incidence of major bleeding in patients who received DAPT in the ED according to the discretion of the treating physician.

Connect with a study center

  • Istishari Hospital

    Amman, 11184
    Jordan

    Site Not Available

  • Istishari Hospital

    Amman 250441, 11184
    Jordan

    Site Not Available

  • Jordan University Hospital

    Amman 250441, 11180
    Jordan

    Active - Recruiting

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