A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Inclusion Criteria:

• Have a history of axial-predominant low back pain

• Have pain that is restricted to the low back or with a referral pattern limited tothe proximal legs

• Have a body mass index (BMI) ≥27 kilograms per square meter (kg/m2) at screening

• Have a history of at least 1 self-reported unsuccessful dietary effort to lose bodyweight

Exclusion Criteria:

• Have a non-axial origin low back pain

• Have had botulinum or steroid injections to the spine within 1 year of screening

• Have had trigger point injection to the spine within 6 months of screening

• Have a self-reported change in body weight >5 kilograms (kg) (11 pounds) within 90days prior to screening

• Have been taking drugs to promote body weight reduction, including over-the-countermedications, within 90 days prior to screening

• Have a prior or planned surgical treatment for obesity

• Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes