An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.

Last updated: March 30, 2026
Sponsor: NGM Biopharmaceuticals, Inc
Overall Status: Active - Recruiting

Phase

2

Condition

Rectal Cancer

Cancer

Colon Cancer; Rectal Cancer

Treatment

Placebo given

NGM120 Q8W

NGM120 Q4W

Clinical Study ID

NCT07033026
120-CX-202
  • Ages > 18
  • All Genders

Study Summary

A multi-center evaluation of NGM120 in a randomized, double-blind, placebo-controlled study in participants with colorectal cancer who have cancer cachexia.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Documented active diagnosis of colorectal cancer.

  2. Cachexia defined by Fearon criteria of weight loss.

  3. Signed informed consent.

Exclusion

Exclusion Criteria:

  1. Current active reversible causes of decreased food intake.

  2. Receiving tube feedings or parenteral nutrition at the time of Screening orRandomization.

  3. Have cachexia caused by other reasons.

Study Design

Total Participants: 136
Treatment Group(s): 3
Primary Treatment: Placebo given
Phase: 2
Study Start date:
June 25, 2025
Estimated Completion Date:
December 31, 2027

Study Description

Evaluation of Efficacy, Safety and Tolerability of NGM120 in a Phase 2, Randomized, Double-blind, Placebo-controlled, Multi-center Study in Participants with Colorectal Cancer who have Cancer Cachexia

Connect with a study center

  • NGM Clinical Study Site

    Tbilisi, 159
    Georgia

    Active - Recruiting

  • NGM Clinical Study Site

    Goyang, 1048
    South Korea

    Active - Recruiting

  • NGM Clinical Study Site

    Incheon, 21565
    South Korea

    Active - Recruiting

  • NGM Clinical Study Site

    Seoul, 6351
    South Korea

    Active - Recruiting

  • NGM Clinical Study Site

    Suwon, 16247
    South Korea

    Active - Recruiting

  • NGM Clinical Study Site

    Taichung, 407216
    Taiwan

    Active - Recruiting

  • NGM Clinical Study Site

    Taipei, 100225
    Taiwan

    Active - Recruiting

  • NGM Clinical Study Site

    Taoyuan District, 333423
    Taiwan

    Active - Recruiting

  • NGM Clinical Study Site

    Los Angeles, California 90033
    United States

    Active - Recruiting

  • NGM Clinical Study Site

    Santa Rosa, California 95403
    United States

    Active - Recruiting

  • NGM Clinical Study Site

    Margate, Florida 33063
    United States

    Active - Recruiting

  • NGM Clinical Study Site

    Baltimore, Maryland 21201
    United States

    Active - Recruiting

  • NGM Clinical Study Site

    New York, New York 10065
    United States

    Active - Recruiting

  • NGM Clinical Study Site

    Toledo, Ohio 43608
    United States

    Active - Recruiting

  • NGM Clinical Study Site

    Youngstown, Ohio 44504
    United States

    Active - Recruiting

  • NGM Clinical Study Site

    Dallas, Texas 75390
    United States

    Active - Recruiting

  • NGM Clinical Study Site

    Kingwood, Texas 77339
    United States

    Site Not Available

  • NGM Clinical Study Site

    Laredo, Texas 78041
    United States

    Active - Recruiting

  • NGM Clinical Study Site

    Richmond, Virginia 23114
    United States

    Active - Recruiting

  • NGM Clinical Study Site

    Appleton, Wisconsin 54915
    United States

    Active - Recruiting

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