Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Inclusion Criteria:

• Elevated fasting TGs and RC

• Elevated nonfasting TGs and RC

• Fasting LDL-C ≥ 50 mg/dL (≥ 1.29 mmol/L) and ≤ 130 mg/dL (≤ 3.36 mmol/L)

• Willingness to provide informed consent and comply with the intervention and allstudy assessments

• Stable diet for a minimum of 3 months prior to screening and with no plans to changeduring screening or trial participation

• Stable drug regimen (if relevant) prior to screening visit and no planned changesduring screening or trial participation

Exclusion Criteria:

• Acute or chronic liver disease

• TG concentration ≥880mg/dl

• History of type 1 diabetes mellitus or history of diabetic ketoacidosis

• Newly diagnosed T2DM

• Participants with known active hepatitis A, B, or C

• Uncontrolled hypothyroidism

• Any condition that prevents the participant from complying with study procedures