A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment

Inclusion Criteria:

A. Inclusion Criteria for Participants with DED:

• The participant reported dry eye-related ocular symptoms for at least 6 monthsbefore the screening visit

• The participant must have either used lubricant eye drops regularly OR had thedesire to use lubricant eye drops in the past 3 months

• Participant must be classified as having moderate/severe DED

• The participant is deemed by the physician to require a prescription medication forDED (e.g., cyclosporin A or lifitegrast)

B. Inclusion Criteria for Healthy Volunteers:

• The participant does not have overt clinical signs of DED in either eye

Exclusion Criteria:

• Intraocular pressure (IOP) >21.00 millimeters of mercury (mmHg) in either eye

• Acute allergic conjunctivitis in either eye within 3 months prior to screening

• Use of contact lenses within 30 days prior to screening

• Punctal plugs within 3 months prior to screening or any history of punctalcauterization or occlusion by an approach different from punctal plugs

• Use of ocular anti-inflammatory agents or ocular immunosuppressive agents within 3months prior to screening

• Any intraocular injections (e.g., intravitreal [IVT] anti-vascular endothelialgrowth factor [VEGF]) within 3 months prior to screening, or such injections plannedfor within the study period

• Any intraocular immunosuppressive implants within 12 months prior to screening

• Any history of isotretinoin use within 12 months prior to screening

• Uncontrolled ocular or systemic disease