Effect of Oxygen Supplementation on Cerebral Oxygenation, Symptoms and Performance During STST in COPD Patients

Last updated: June 9, 2025
Sponsor: George Papanicolaou Hospital
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Emphysema

Bronchiectasis

Chronic Obstructive Lung Disease

Treatment

Oxygen

medical air

Clinical Study ID

NCT07024914
GeorgePH39/16-01-2019
  • All Genders

Study Summary

It is a randomised, single-blind trial of the effect of acute oxygen supplementation on cerebral oxygenation during the 30 sec Sit-To-Stand Test (STST) in chronic obstructive pulmonary disease patients, without resting hypoxemia. After an initial clinical assessment, patients preform the 30sec STST under near-infrared spectroscopy, a non invasive technique which assesses cerebral oxygenation at the prefrontal lobe. Measurements are performed twice, under oxygen supplementation or medical air, in a random order, and the patients are be blinded to the treatment (oxygen or medical air) given.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. clinical diagnosis of COPD, based on smoking history of at least 100 cigarettes andpost bronchodilation forced expiratory volume (FEV1) to forced vital capacity (FVC)ratio <0.7, and 2) resting arterial oxygen partial pressure >60 mmHg, according torecent (within a week) arterial blood gases assessment.

Exclusion

Exclusion Criteria:

  1. recent COPD exacerbation (as indicated by deterioration of respiratory symptoms,hospital admission and/or change in medication within the previous month), 2)history of specific balance problems (i.e., diagnosed neurological or vestibulardisorder), 3) spinal surgery, and 4) lower limb musculoskeletal problems (i.e.,surgery, injury or pathology at hip, knee, ankle or foot)

Study Design

Total Participants: 25
Treatment Group(s): 2
Primary Treatment: Oxygen
Phase:
Study Start date:
September 18, 2019
Estimated Completion Date:
December 31, 2025

Connect with a study center

  • Papanikolaou General Hospital

    Thessaloniki, 57010
    Greece

    Site Not Available

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