POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS

Inclusion Criteria POTS patients:

• Previously diagnosed with POTS in tilt test or active stand-test (either newlydiagnosed within last 3 months or in new tilt test/active stand test duringscreenings visit)

• Reproducible orthostatic intolerance with raise in HR on >30 bpm when standingwithin 10 minutes of change of supine to standing in age >19 years or >40 bpm in age 18-19 years.

• POTS symptoms/orthostatic intolerance

• Age 18-50

• Waist ratio <180 cm

Exclusion Criteria:

• Chronic illness

• Metallic implants

• Above 10 alcoholic drinks or week or substance abuse

• Other types of sinus tachycardia or heart disease

• Liverenzymes two times above normal values

• Decreased kidney function eGFR <90 or elevated kreatinkinasis

• Thyroid disease or TSH out of reference

• Uncontrollable low or high blood pressure

• Blood vessels that cannot be visualized on MR

• Any disease that might influence the health of the participant during the study orparticipants that receives medicine that cannot be paused for 36 hours

Inclusion Criteria:

• Age 18-50

• Waist ratio <180 cm

• Matched a POTS patient in age, sex and BMI

Exclusion Criteria:

• Chronic illness

• Metallic implants

• Above 10 alcoholic drinks or week or substance abuse

• POTS; other types of sinus tachycardia or heart disease

• Liverenzymes two times above normal values

• Decreased kidney function eGFR <90 or elevated kreatinkinasis

• Thyroid disease or TSH out of reference

• Uncontrollable low or high blood pressure, Orthostatic hypotension

• Blood vessels that cannot be visualized on MR

• Any disease that might influence the health of the participant during the study orparticipants that receives medicine that cannot be paused for 36 hours