Association of Plasma N-terminal Pro-Brain Natriuretic Peptide Levels With the Burden of Coronary Artery Disease

Last updated: June 5, 2025
Sponsor: IRCCS Ospedale San Raffaele
Overall Status: Active - Recruiting

Phase

N/A

Condition

Coronary Artery Disease

Atherosclerosis

Thrombosis

Treatment

BNP

Clinical Study ID

NCT07013344
BNP-CAD-HSR-2025
  • Ages > 18
  • All Genders

Study Summary

This study aim to investigate the association between plasma NT-proBNP levels and the presence, extent and severity of stenosis in patients with suspected coronary artery disease.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patient referred for elective coronary angiography due to suspected CAD.

  • NT-proBNP measurement during hospitalization

Exclusion

Exclusion Criteria:

  • heart failure

  • severe valvular disease

  • atrial fibrillation

  • severe chronic kidney disease (eGFR < 30 mL/min)

  • prior coronary artery bypass grafting

  • age over 80 years

Study Design

Total Participants: 800
Treatment Group(s): 1
Primary Treatment: BNP
Phase:
Study Start date:
September 01, 2021
Estimated Completion Date:
July 31, 2025

Study Description

The investigators prospectively measured plasma NT-proBNP levels in consecutive patients referred to the center for elective diagnostic coronary angiography due to symptoms or signs of coronary artery disease over a two- year period. Patients with conditions known to elevate NT-proBNP levels, including heart failure, severe valvular disease, atrial fibrillation, severe chronic kidney disease (eGFR < 30 mL/min), prior coronary artery bypass grafting, or age over 80 years, were excluded.

Connect with a study center

  • IRCCS San Raffaele Hospital

    Milan, 20132
    Italy

    Completed

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