Treatment of Plane Warts With Topical and Oral Retinoids

Last updated: June 8, 2025
Sponsor: Tishreen University
Overall Status: Completed

Phase

4

Condition

Warts

Treatment

Topical tretinoin 0.05% + oral isotretinoin (0.5 mg/kg/day)

Topical tretinoin 0.05%

Clinical Study ID

NCT07012811
TishreenU - Plane Warts
  • Ages > 12
  • All Genders

Study Summary

The aim of this study was to compare the effectiveness and safety of topical tretinoin cream 0.05% alone against combination with oral isotretinoin (0.5 mg/kg/day) for treatment of plane warts.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients above 12 years diagnosed with plane warts.

  • Patients who had not received any treatment for warts in the last month.

Exclusion

Exclusion Criteria:

  • Pregnancy and lactation.

  • Abnormal lipid profile.

  • Significant hepatic or renal dysfunction.

  • Depression.

Study Design

Total Participants: 39
Treatment Group(s): 2
Primary Treatment: Topical tretinoin 0.05% + oral isotretinoin (0.5 mg/kg/day)
Phase: 4
Study Start date:
February 12, 2024
Estimated Completion Date:
March 30, 2025

Study Description

This study included 39 patients divided into two groups. Treatment was given for three months duration. Patients were followed-up for further three months to assess the recurrence rate. Combination treatment led to a faster resolution and a higher percentage of complete response. It presents a promising effective alternative option for treatment of plane warts.

Connect with a study center

  • Tishreen University- Faculty of Medicine

    Latakia,
    Syrian Arab Republic

    Site Not Available

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