Effect of Transauricular Vagal Stimulation on Cardiac Function After Spinal Cord Injury

Last updated: June 3, 2025
Sponsor: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Spinal Cord Injuries

Treatment

Active Transauricular Vagus Nerve Stimulation

Sham Transauricular Vagus Nerve Stimulation

Clinical Study ID

NCT07007884
E2-23-3620
  • Ages 18-60
  • All Genders

Study Summary

The aim of this study is to investigate the effect of transauricular vagal nerve stimulation (taVNS) on cardiac autonomic functions in patients with spinal cord injury (SCI).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Aged between 18-60

  2. Having a traumatic spinal cord injury

  3. Cervical spinal cord injury patients with a history of autonomic dysreflexia

  4. At least 6 months after the injury

  5. Signing an informed consent form showing consent to participate in the study

Exclusion

Exclusion Criteria:

  1. Having a cardiac or neural pacemaker

  2. Presence of pregnancy

  3. Clinical coronary artery disease confirmed by invasive or coronary computedtomographic angiography

  4. History of acute coronary syndrome (unstable angina, myocardial infarction)

  5. Documented arrhythmia and/or use of antiarrhythmic drugs on ECG

  6. Diagnosis of hypertension and use of antihypertensive drugs

  7. Damaged skin lesion in the application area

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: Active Transauricular Vagus Nerve Stimulation
Phase:
Study Start date:
March 20, 2024
Estimated Completion Date:
September 30, 2025

Study Description

Spinal cord injury impairs autonomic pathways and ultimately cardiovascular homeostasis. Spinal cord injury affects the autonomic system, resulting in impaired cardiac autonomic functions. This study is designed to evaluate the effect of transauricular vagal nerve stimulation (taVNS) on cardiac autonomic functions in patients with spinal cord injury.

Connect with a study center

  • SBÜ Gaziler Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi

    Ankara,
    Turkey

    Active - Recruiting

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