Proving Utility of a New Field-cycling MRI Prototype in Acute Stroke Patients

Phase

N/A

Condition

Stroke

Cerebral Ischemia

Treatment

Follow up 3T MRI research scan

Field-Cycling Imaging research scan

3T MRI research scan

Clinical Study ID

NCT07004140

2-001-25

25/SS/0021

Ages > 18
All Genders

Study Summary

The goal of this study is to test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can show changes in the brain within the first day of a stroke due to a blocked blood vessel or bleeding in the brain. The main question it aims to answer is:

• Can FCI identify brain tissue that might recover within the first few hours after a stroke begins?

Participants will undergo a standard MRI scan and an FCI scan, as soon as possible after hospital admission.

Participants who have had a blocked blood vessel will also provide a blood sample and will have a follow up visit at 30 days for repeat of both scans and providing another blood sample.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Acute stroke (<24 hours from symptom onset).
NIHSS ≥4 and <25 with cortical involvement and/or large vessel occlusion on baselineimaging.
Able to undergo 3T and FCI MRI <24h of onset.
With or without thrombolysis.

Exclusion

Exclusion Criteria:

Contraindications to MRI.
Medically unstable.
Unable to comprehend or comply with instructions regarding scanning
Prior mRS of >3.
Identified for thrombectomy.
Non-stroke pathology or previous cortical infarct on CT scan > 1/3 of middlecerebral artery territory.

Study Design