Clinical Efficacy Trial of Burdock Root Extract in Patients With Asymptomatic Hyperuricaemia

Inclusion Criteria:

• Hyperuricaemia confirmed by a laboratory, uric acid level from 360 to 540 μmol/L inwomen and from 420 to 540 μmol/L in men;

• Age from 35 to 65 years at the baseline;

• Patients examined by an experienced specialist not revealing any clinicalevidences of gout or other somatic consequences of hyperuricaemia;

• Not taking any other nutritional additives;

• Women of reproductive age having negative pregnancy test at the baseline and atthe end of the trial;

• Not taking any diuretics, or their administration based on a regimen usual fora patient, without changes;

• Not taking part in any other clinical trials;

• Consent and voluntarily signed informed consent form for participation in theclinical trial.

Exclusion Criteria:

• Age <35 or >65 years;

• Fever (above 36.8 оС);

• Pregnancy and lactation;

• Patients with any somatic evidences of hyperuricaemia including gout taking antigoutdrugs during or within 6 months before the trial;

• Patients with mental disorders / taking antipsychotics or antidepressants;

• Patients not giving (informed) consent to participate in the trial;

• Patients causing doubts of the study doctor as to their motivation to comply withthe trial;

• Presence of any concomitant decompensated diseases or acute conditions able toinfluence results of the trial;

• Alcohol abuse and drug addiction;

• Changes in taking diuretics within a month before and during the trial;

• Participation in any other clinical trial;

• Taking any nutritional additives.