Evaluation of the Efficacy and Safety of Polatuzumab Vedotin Combined With Rituximab, Gemcitabine, and Oxaliplatin (Pola-R-GemOx) as Salvage Therapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) Patients Ineligible for Autologous Transplantation

Inclusion Criteria:

• Participants must meet all of the following criteria to participate in the study:

1. Age ≥18 years old;

2. ineligible for autologous transplantation;

3. Sign the Informed Consent Form (ICF);

4. CD79b-positive DLBCL confirmed by pathology (including transformed DLBCL, PMBL,HGBCL);

5. Patients must have received adequate first-line treatment and only first-linetreatment, with

• Anti-CD20 monoclonal antibodies (unless the investigator determines that thetumor is CD20-negative)

• Chemotherapy regimens containing anthracyclines

6. Recurrent or refractory diseases after first-line immunochemotherapy:

• Refractory disease is defined as not having a complete response to first-linetherapy (except for patients who are intolerant to first-line therapy)

• Recurrent disease is defined as disease recurrence after complete response tofirst-line treatment

7. Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2, with anexpected survival of more than 12 weeks.

8. Have at least one measurable two-dimensional lesion identified by clinicalexamination, CT scan or MRI: ① lymph node >1.5cm; ② Other non-lymph node lesions ≥1.0cm;

9. The main tissues and organs function well:

Hematological function: absolute granulocyte count ≥ 1,000/mm3, platelet count ≥ 75,000/mm3; Liver function: ALT/AST < 3 times upper limit of normal (ULN) and total bilirubin ≤1.5× upper limit of normal (ULN) (< 5 times ULN in patients with Gilbert syndrome, cholestasis due to hilar compression adenopathy, biliary obstruction due to liver involvement or lymphoma); Renal function: creatinine clearance > 30 mL/min, creatinine ≤1.5× upper limit of normal (ULN) Lung function: indoor oxygen saturation ≥95%; Cardiac function: no obvious cardiac insufficiency or cardiovascular disease; 10. Fertile patients must be willing to use highly effective contraception during the study period and for 120 days after the last dose of treatment.

Exclusion Criteria:

• Subjects who meet any of the following criteria are not eligible to participate in this study:

1. Subjects with any factor that may affect their ability to comply with the protocol,as determined by the investigator, including uncontrollable medical, psychological,family, social, or geographical conditions, or those unwilling or unable to followthe procedures required by the study protocol.

2. Known human immunodeficiency virus (HIV) infection or immunoassay positive；

3. Viral infections that cannot be controlled by antiviral drugs, such as active herpesvirus infection, acute or chronic active hepatitis B, acute or chronic activehepatitis C, etc. (Note: chronic HBV carriers or inactive HBsAg positive subjectswith HBV-DNA lower than the lower limit of detection can be enrolled, requiringclinical evaluation and preventive antiviral therapy if appropriate; HCV antibodynegative can be enrolled, HCV antibody positive patients need to test HCV-RNA, ifnegative can be enrolled)

4. Patients with uncontrolled lymphomas with CNS infiltration (CNS disease diagnosed atinitial diagnosis is allowed, provided complete remission of CNS disease is achievedand maintained and no CNS disease is present at recurrence);

5. Patients who have previously received oxaliplatin or gemcitabine treatment;

6. Pregnant or lactating patients;

7. Other concurrent serious illness or medical condition that would preventparticipation in the study;