Phase 2 Study of ADX-038 in Participants With Geographic Atrophy

Inclusion Criteria:

• Clinical diagnosis of GA of the macula secondary to AMD

• GA lesions between 2.5 and 12.5 mm2 at screening

• Sufficiently clear ocular media, adequate pupillary dilation and fixation to permitquality fundus imaging in the study eye as described in the protocol

• Willing and able to comply with clinic visits and study-related procedures,including completion of the full series of meningococcal vaccinations andpneumococcal vaccination required per protocol

Exclusion Criteria:

• Has GA secondary to causes other than AMD

• Has active ocular disease that compromises or confounds visual function

• History of surgery for retinal detachment

• Has ocular condition other than GA secondary to AMD

• Use of intravitreal complement inhibitors in study eye

• Hereditary or acquired complement deficiency

• Active viral, bacterial or fungal infection

• Liver injury as evidenced by abnormal liver function tests

• Donating blood

• History of choroidal neovascularization in the study eye