Phase
Condition
Thrombocytopenia And Thrombocytopenia Prevention
Soft Tissue Infections
Treatment
Local standard medical care
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participant must be 18 years of age inclusive, at the time of signing the informedconsent.
Participants with diagnosed sepsis according to sepsis-3 definition.
Participants with documented suspected origin of infection.
Informed consent of capable participant or, in case of participant being incapableof giving informed consent, consent for study inclusion will be sought according toapplicable laws and regulations.
Exclusion
Exclusion Criteria:
Patients deferred from other Intensive Care Units (ICUs).
Patients longer than 24 hours on ICU.
Known coagulation disorder.
Ongoing active clinically significant bleeding.
Participants experienced trauma or major surgery (within 4 weeks).
Active malignancy.
Decompensated liver impairment Child-Pugh Class C.
Moribund patients not expected to survive 24 hours (clinical decision).
Ongoing therapeutic anticoagulation (prophylactic dose of Unfractionated Heparin [UFH]/Low Molecular Weight Heparin [LMWH] is allowed) or antiplatelet therapy (except low dose [≤100 mg] acetyl salicylic acid [ASA]). If previously namedtreatment can be stopped the participants will be eligible if a "wash out"-time offive half-lives is applied before start of study.
Patients who have received any investigational drug involving pharmacologicalinterventions, or biological or cell therapy interventions or prohibited therapywithin 28 days or five half-lives, whichever is longer, prior to screening/baseline.
Any reason that would make participation unadvisable, at the discretion of theinvestigator.
Study Design
Connect with a study center
MedUni Graz | Innere Medizin, ICU
Graz, 8036
AustriaSite Not Available
MedUni Innsbruck | Innere Medizin I, Internistische Intensiv- und Notfallmedizin
Innsbruck, 6020
AustriaActive - Recruiting
MedUni Wien | Univ. Klinik für Klinische Pharmakologie
Vienna, 1090
AustriaSite Not Available
AZ Groeninge - Campus Kennedylaan
Kortrijk, 8500
BelgiumActive - Recruiting
Centre Hospitalier Universitaire (CHU) de Liege - Domaine Universitaire du Sart Tilman
Liège, 4000
BelgiumActive - Recruiting
Clinique Saint-Pierre d'Ottignies - Intensive Care
Ottignies-Louvain-La-Neuve, 1340
BelgiumActive - Recruiting
Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc
Woluwe Saint Lambert, 1200
BelgiumSite Not Available
Centre Hospitalier Universitaire d'Angers - Médecine Intensive Réanimation et Médecine Hyperbare
Angers, 49100
FranceActive - Recruiting
Hôpital Raymond-Poincaré - Service de Médecine Intensive - Réanimation, Médecine Hyperbare
Garches, 92380
FranceActive - Recruiting
Centre Hospitalier Départemental Vendée - Service de réanimation polyvalente
La Roche-Sur-Yon, 85000
FranceSite Not Available
Centre Hospitalier Universitaire de Limoges Dupuytren 1 - Service de réanimation polyvalente
Limoges, 87042
FranceActive - Recruiting
Hopital Hotel Dieu Nantes - Service de Médecine Intensive Réanimation
Nantes, 44000
FranceActive - Recruiting
Hopitaux Universitaires de Strasbourg Nouvel Hopital Civil - Service de Médecine Intensive Réanimation
Strasbourg, 67091
FranceActive - Recruiting
CHRU de Tours - Hôpital Bretonneau - Médecine Intensive Réanimation
Tours, 37044
FranceActive - Recruiting
Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik
Köln, Nordrhein-Westfalen 51109
GermanySite Not Available
Universitaetsklinikum Carl Gustav Carus an der Technischen Universitaet Dresden | Medizinische Klinik I - FB Haemostaseologie
Dresden, 01307
GermanySite Not Available
Universitaetsklinikum Essen | Klinik für Anaesthesiologie und Intensivmedizin
Essen, 45147
GermanySite Not Available
Universitaetsklinikum Schleswig-Holstein, Campus Kiel | Klinik für Anaesthesiologie und Operative Intensivmedizin
Kiel, 24105
GermanySite Not Available
RKH Klinikum Ludwigsburg
Ludwigsburg, 71640
GermanySite Not Available
Klinikum der Universität München AöR - Klinik für Anaesthesiologie (Campus Großhadern)
München, 81377
GermanySite Not Available
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Anestesia e TI Polivalente
Bologna, 40138
ItalyActive - Recruiting
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo_Ospedale S. Carlo - Anestesia e Rianimazione
Milano, 20153
ItalySite Not Available
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Anestesia, Rianimazione, Terapia Intensiva e Tossicologia Clinica
Roma, 00168
ItalyActive - Recruiting
Humanitas Mirasole S.p.A. - Anestesia e Terapie Intensive
Rozzano, 20089
ItalyActive - Recruiting
Medisch Spectrum Twente - Intensive Care
Enschede, 7512 KZ
NetherlandsActive - Recruiting
Universitair Medisch Centrum St. Radboud
Nijmegen, 6500HB
NetherlandsSite Not Available
Maasstad
Rotterdam, 3079 DZ
NetherlandsActive - Recruiting
Hospital Central de Asturias
Oviedo, Asturias 33011
SpainActive - Recruiting
Hospital Universitario de Getafe
Getafe, Madrid 28905
SpainActive - Recruiting
Hospital Universitario de Getafe - UCI
Getafe, Madrid 28905
SpainActive - Recruiting
Hospital Universitari Vall d'Hebron
Barcelona, 08035
SpainActive - Recruiting
Hospital Clinico San Carlos
Madrid, 28040
SpainActive - Recruiting
Hospital Virgen del Rocio
Sevilla, 41013
SpainActive - Recruiting
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