A Phase 2 Study of the Safety and Efficacy of Brepocitinib in Adults With Cutaneous Sarcoidosis (BEACON)

Inclusion Criteria:

1. Adults subjects (18-74)

2. Cutaneous sarcoidosis with characteristic skin biopsy histology

3. A CSAMI activity score ≥ 10

4. Weight > 40 kg to < 130 kg with BMI < 40 kg/m2 .

Exclusion Criteria

1. History of

• Lymphoproliferative disorder

• Active malignancy;

• History of cancer within 5 years prior to baseline (exceptions for basal cell carcinoma, squamous cell carcinoma, or carcinoma in situ of the uterine cervix).

2. High risk of thrombosis or cardiovascular disease

3. High risk of herpes zoster

4. Active or recent infection