Association of C-reactive Protein-albumin-lymphocyte Index (CALLY) With All-cause Mortality in Diabetic Patients

Last updated: May 8, 2025
Sponsor: Kunming Children's Hospital
Overall Status: Completed

Phase

N/A

Condition

Diabetic Vitreous Hemorrhage

Diabetic Neuropathy

Diabetic Foot Ulcers

Treatment

N/A

Clinical Study ID

NCT06976359
20250508CALLY
The 14th Five-Year Plan Yunnan
  • Ages > 40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Based on retrospective cohort data from 3,988 diabetic patients in the NHANES database, this study is the first to show a significant negative correlation between the CALLY index and all-cause mortality in diabetic patients, with good predictive ability for their survival risk. Our findings can help clinicians better assess disease progression in diabetic patients and provide a reference for personalized, precision medicine.

Eligibility Criteria

Inclusion

Inclusion Criteria:

(1) self-reported doctor-diagnosed diabetes; (2) fasting blood glucose ≥ 7.0 mmol/L; (3) two-hour oral glucose tolerance test blood glucose ≥ 11.1 mmol/L; (4) glycated hemoglobin A1c (HbA1c) ≥ 6.5%; or (5) use of hypoglycemic medication.

Study Design

Total Participants: 3988
Study Start date:
April 08, 2025
Estimated Completion Date:
May 08, 2025

Study Description

All analyses accounted for NHANES sample weights, clustering, and stratification. We used EmpowerStats (v4.1, www.empowerstats.com) and R software (v4.4.1, www.r-project.org). Continuous variables were expressed as weighted mean ± standard error (SE), and categorical variables as weighted percentages. Associations between the CALLY index and all-cause mortality were assessed using Cox proportional hazards models. Model 1 was the unadjusted crude model. Model 2 included adjustments for age, sex, race, BMI, PIR, education, smoking, and alcohol consumption. Model 3 was the fully adjusted model including additional covariates, HDL, TC, BUN, uric acid, SCR, physical activity, energy intake, hypertension, CVD. Kaplan-Meier survival curves were used to compare survival across CALLY quartiles; differences were assessed using log-rank tests. Nonlinear associations were examined with smoothed curve fitting. Subgroup analyses explored consistency across strata. ROC curves and AUC were used to compare the predictive performance of CALLY, SII, PLR, and NLR. P < 0.05 was considered statistically significant.

Connect with a study center

  • Kunming Children's Hospital

    Kunming, Yunnan 650000
    China

    Site Not Available

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