PET/MRI/EEG Imaging Study in Epilepsy

Last updated: May 8, 2025
Sponsor: Massachusetts General Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Epilepsy

Treatment

FDG-PET/fMRI/EEG imaging

Clinical Study ID

NCT06974305
2022P000929
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography [FDG-PET], and blood flow, measured by functional magnetic resonance imaging [fMRI]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography [EEG]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18 or older

Additional Inclusion Criteria for Subjects with Epilepsy:

  • Diagnosed with epilepsy with abnormal interictal EEG

Exclusion

Exclusion Criteria:

  • Contraindications to PET, MRI, or EEG imaging

  • History of severe brain disease such as stroke and head trauma

  • History of brain surgery

  • History of type I or II diabetes mellitus

  • Fasting plasma glucose level >200 mg/dL

  • Employed under direct supervision of the PI conducting the research

Additional Exclusion Criteria for Healthy Subjects:

  • Current use of drugs that modulate brain function

  • Current or past history of major medical, neurological, or psychiatric conditions

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: FDG-PET/fMRI/EEG imaging
Phase:
Study Start date:
September 21, 2023
Estimated Completion Date:
November 30, 2025

Connect with a study center

  • Athinoula A. Martinos Center

    Charlestown, Massachusetts 02129
    United States

    Active - Recruiting

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