A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity

Inclusion Criteria:

• Have body mass index (BMI) ≥30 kilograms per square meter (kg/m2) or BMI ≥25.0 kg/m2and at least 1 of the following weight-related comorbidities at screening:

• hypertension

• dyslipidemia

• obstructive sleep apnea, or

• cardiovascular disease

• Have a history of at least one unsuccessful dietary effort to lose body weight

Exclusion Criteria:

• Have type 1 diabetes, type 2 diabetes, or any other types of diabetes

• Have an unstable body weight within 90 days prior to screening

• Have New York Heart Association functional classification IV congestive heartfailure or an acute cardiovascular condition within 90 days prior to screening

• Have acute or chronic hepatitis or pancreatitis

• Are taking other medications or alternative remedies to manage weight loss