Phase
Condition
N/ATreatment
Placebo
Nicotinamide Riboside (NR)
Clinical Study ID
Ages 40-60 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participant must be 40 to 60 years of age inclusive, at the time of signing theinformed consent.
Male or female.
Participants who are healthy as determined by medical evaluation including medicalhistory and physical examination.
Capable of giving signed informed consent which includes compliance with therequirements and restrictions listed in the study protocol.
Self-reported normal sleep patterns, assessed by Pittsburgh sleep quality index (PSQI; cutoff ≤ 5).
No current use of sleep medications or supplements.
Able to wear polysomnographic equipment and actigraphy during nighttime.
Exclusion
Exclusion Criteria:
History of sleep disorders (e.g. insomnia, sleep apnea).
Abnormal findings on PSG, such as sleep related breathing disorders (apnea-hypopneaindex (AHI) ≥ 5), sleep related movement disorders (periodic limb movement index (PLMI) ≥ 15, and parasomnias (like REM sleep behavior disorder (RBD)).
Chronic use of alcohol, tobacco, or medications affecting sleep.
Significant psychiatric or medical conditions (including neurological, heart, lung,or sleep disorders/diseases).
Travelled >1 time zone and night work <1 month before study, or during the study.
Extreme chronotype according to the Composite Morningness Questionnaire (eveningtype; <22 and morning type >44).
Pregnancy.
Breastfeeding.
Supplements resulting in > 20 mg daily of nicotinamide riboside, nicotinamidemononucleotide (NMN), niacin (vitamin B3, nicotinic acid amide or other vitamin B3analogues) less than 3 months prior to randomization.
Participation in other clinical trials last 3 months.
Deemed ineligible by lead principal investigator.
Study Design
Study Description
Connect with a study center
Haukeland University Hospital
Bergen,
NorwayActive - Recruiting
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