Hydrogen-Rich Water and Metabolic Health in Adults: A 12-Week Randomized Trial

Last updated: May 5, 2025
Sponsor: University of Novi Sad, Faculty of Sport and Physical Education
Overall Status: Active - Recruiting

Phase

N/A

Condition

High Cholesterol (Hyperlipidemia)

Diabetes Prevention

Metabolic Disorders

Treatment

Experimental 3: low-breath hydrogen

Experimental 4: high-breath hydrogen

Experimental 1: low-breath hydrogen

Clinical Study ID

NCT06968715
51-02-01
  • Ages 30-65
  • All Genders

Study Summary

The HYDRO-RESPOND trial is a 12-week randomized controlled study investigating the effects of daily hydrogen-rich water (HRW) consumption on body composition and metabolic biomarkers in adults diagnosed with metabolic syndrome. The study also explores whether individual differences in baseline breath hydrogen levels influence response to HRW. Participants are randomly assigned to receive either HRW or a placebo, with outcomes including changes in body fat, waist circumference, glucose metabolism, lipid profiles, and inflammatory markers. The trial aims to determine the therapeutic potential of HRW and identify predictors of individual responsiveness.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 30-65 years

  • Metabolic syndrome (NHS) (at least 3 of the 5 following criteria):

  • Waist circumference of ≥ 102 cm in men and ≥ 88 cm in women

  • Hypertriglyceridemia (≥ 1.695 mmol/L)

  • Low HDL-C (< 1.04 mmol/dL in men and < 1.30 mmol/dL in women)

  • High blood pressure (> 130/85 mmHg)

  • High fasting glucose (> 6.1 mmol/L)

  • Not physically active

  • Informed consent signed

Exclusion

Exclusion Criteria:

  • Major chronic disease and acute injuries

  • History of dietary supplement use during the past 4 weeks

  • History of metabolism-modulating pharmaceuticals use during the past 4 weeks

  • No consent to randomization

  • Participation in other studies

Study Design

Total Participants: 40
Treatment Group(s): 4
Primary Treatment: Experimental 3: low-breath hydrogen
Phase:
Study Start date:
April 01, 2025
Estimated Completion Date:
November 30, 2025

Connect with a study center

  • Applied Bioenergetics Lab at Faculty of Sport and PE

    Novi Sad, Vojvodina 21000
    Serbia

    Active - Recruiting

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