Respiratory Virus Infections in Acute Heart Failure

Phase

N/A

Condition

Chest Pain

Heart Failure

Hyponatremia

Treatment

N/A

Clinical Study ID

NCT06967441

SNUBH IRB NO: B-2412-941-302

Ages > 19
All Genders

Study Summary

Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort.

The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Adult aged 19 years or older admitted to the cardiology department with acute heartfailure
NT-proBNP >300 pg/mL
Clinician judgement of possible respiratory viral infection (fever >38 degrees orcough, respiratory symptoms such as sputum or consolidation on x-ray or CRP >5mg/dL)
Patients who have a nasopharyngeal swab for respiratory virus PCR test performedwithin 72 hours of admission for any of the 3 reasons

Exclusion

Exclusion Criteria:

Patients with a clear other cause of acute heart failure (ex. ACS, bradycardiarequiring a pacemaker, uncontrolled tachycardia, uncontrolled severe hypertension (SBP >180mmHg or DBP >110mmHg), haemoglobin <7g/dL or AHF precipitated by medicationnon-adherence)
If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD
If there is a clear other source of infection that can explain the fever

Study Design

April 07, 2025

December 31, 2028

Connect with a study center

Seoul National University Bundang Hospital
Seongnam, Gyeonggi-do 13620
Korea, Republic of
Site Not Available
Samsung medical center
Seoul,
Korea, Republic of
Active - Recruiting
Seoul ST. Mary's Hospital
Seoul,
Korea, Republic of
Active - Recruiting
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do 13620
South Korea
Active - Recruiting
Samsung medical center
Seoul,
South Korea
Active - Recruiting
Seoul ST. Mary's Hospital
Seoul,
South Korea
Active - Recruiting

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