Respiratory Virus Infections in Acute Heart Failure

Last updated: May 4, 2025
Sponsor: Minjae Yoon
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Failure

Chest Pain

Congestive Heart Failure

Treatment

N/A

Clinical Study ID

NCT06967441
SNUBH IRB NO: B-2412-941-302
  • Ages > 19
  • All Genders

Study Summary

Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort.

The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult aged 19 years or older admitted to the cardiology department with acute heartfailure

  • NT-proBNP >300 pg/mL

  • Clinician judgement of possible respiratory viral infection (fever >38 degrees orcough, respiratory symptoms such as sputum or consolidation on x-ray or CRP >5mg/dL)

  • Patients who have a nasopharyngeal swab for respiratory virus PCR test performedwithin 72 hours of admission for any of the 3 reasons

Exclusion

Exclusion Criteria:

  • Patients with a clear other cause of acute heart failure (ex. STEMI, bradycardiarequiring a pacemaker, SBP >200mmHg or DBP >110mmHg, haemoglobin <7g/dL)

  • If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD

  • If there is a clear other source of infection that can explain the fever

Study Design

Total Participants: 360
Study Start date:
April 07, 2025
Estimated Completion Date:
December 31, 2028

Connect with a study center

  • Seoul National University Bundang Hospital

    Seongnam, Gyeonggi-do 13620
    Korea, Republic of

    Active - Recruiting

  • Samsung medical center

    Seoul,
    Korea, Republic of

    Active - Recruiting

  • Seoul ST. Mary's Hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

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