The Application of Lidocaine Cream on Oral Secretions of LMA Removal During the Recovery Period in Ophthalmic Surgical Patients Under General Anesthesia

Last updated: May 15, 2025
Sponsor: Sun Yat-sen University
Overall Status: Active - Recruiting

Phase

4

Condition

Anesthesia

Saliva And Salivary Gland Dysfunction

Treatment

lidocaine cream

Placebo

Clinical Study ID

NCT06967064
2000035364
  • Ages 18-60
  • All Genders

Study Summary

The application of lidocaine cream on oral secretions of LMA removal during the recovery period in ophthalmic surgical patients under general anesthesia: a randomized controlled trial

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged 18 to 60 years;

  • With American Society of Anesthesiologists (ASA) physical status I or II;

  • Scheduled to undergo ophthalmic surgery following general anesthesia with LMA.

Exclusion

Exclusion Criteria:

  • Contraindications to LMA use;

  • A history of upper respiratory tract infection within one week prior to surgery;

  • Persistent pharyngeal symptoms (eg. throat irritation, dryness, or chronic cough,etc.) lasting ≥ 3 months;

  • Severe gastroesophageal reflux disease;

  • Morbid obesity, defined as a body mass index ≥ 40 kg/m2;

  • A predicted difficult airway (eg. a history of difficult airway, mouth opening < 3cm, Mallampati class 4, limited neck extension or cervical spine disease);

  • Presence of structural abnormalities, masses, infections, or scarring in the oralcavity or oropharynx;

  • Known contraindications to lidocaine cream;

  • Two or more failed attempts at LMA insertion;

  • Intraoperative administration of anticholinergic agents;

  • Any other condition present likely to influence the study outcomes.

Study Design

Total Participants: 45
Treatment Group(s): 2
Primary Treatment: lidocaine cream
Phase: 4
Study Start date:
May 15, 2025
Estimated Completion Date:
July 15, 2025

Study Description

During the recovery from general anesthesia, patients commonly experience heightened oral secretions, which can elevate intraocular pressure (IOP) due to coughing and potentially lead to the infiltration of secretions into the surgical site via the nasolacrimal duct, increasing the risk of endophthalmitis. This study is aimed to investigate whether applying lidocaine cream to the laryngeal mask airway (LMA) reduces oral secretions during emergence from general anesthesia in ophthalmic surgery patients.

Connect with a study center

  • Zhongshan Ophthalmic Center, Sun Yat-sen University

    Guangzhou, Guangdong 510060
    China

    Active - Recruiting

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