Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

Phase

Condition

Urothelial Carcinoma

Kidney Cancer

Prostate Disorders

Treatment

DCC-2812

Clinical Study ID

NCT06966024

DCC-2812-01-001

Ages > 18
All Genders

Study Summary

This is a multicenter clinical trial to evaluate the safety and preliminary activity of the selective general control nonderepressible 2 (GCN2) activator DCC-2812 as monotherapy in advanced/metastatic renal cell carcinoma (RCC), urothelial carcinoma, and castration-resistant prostate cancer.

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

Have confirmed Advanced or Metastatic Renal Cell Carcinoma, Urothelial Cancer, orCastration-Resistant Prostate Cancer
Able to take oral medication
If a female is of childbearing potential, must have a negative pregnancy test priorto enrollment and all participants agree to follow the contraception requirements
Adequate organ function and electrolytes

Exclusion

Key Exclusion Criteria:

Received any prior anticancer therapy or any investigational therapy within aspecified timeframe prior to first dose of DCC-2812
Impaired cardiac function
Major surgery within 28 days of the first dose of study drug

Study Design

DCC-2812

August 27, 2025

February 28, 2029

Connect with a study center

Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
Active - Recruiting
Dana-Farber Cancer Institute
Boston 4930956, Massachusetts 6254926 02215
United States
Site Not Available
Vanderbilt- Ingram Cancer Center
Nashville, Tennessee 37232
United States
Active - Recruiting
NEXT Oncology, Austin
Austin, Texas 78758
United States
Active - Recruiting
NEXT Oncology
San Antonio, Texas 78229
United States
Site Not Available
NEXT Oncology, San Antonio
San Antonio, Texas 78229
United States
Active - Recruiting
NEXT Austin
Austin 4671654, Texas 4736286 78758
United States
Active - Recruiting
NEXT Oncology, Austin
Austin 4671654, Texas 4736286 78758
United States
Site Not Available
NEXT Oncology
San Antonio 4726206, Texas 4736286 78229
United States
Active - Recruiting
NEXT Oncology, San Antonio
San Antonio 4726206, Texas 4736286 78229
United States
Site Not Available

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