A Phase I/IIa Study of JAB-23E73 in Patients With Advanced Solid Tumors Harboring KRAS Gene Alteration

Inclusion Criteria:

1. Histological or cytologically proven diagnosis of a locally advanced, unresectable,and/or metastatic solid tumor cancer with evidence of KRAS gene alteration (including gene mutation and wild type amplification).

2. Able to provide an archived tumor tissue sample or fresh biopsy sample.

3. Life expectancy ≥3 months at the start of treatment.

4. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

5. ≥1 measurable lesion per RECIST v1.1.

6. Adequate organ function.

Exclusion Criteria:

1. Unable to swallow oral medications or with gastrointestinal dysfunction orgastrointestinal disease that significantly alters the absorption of medication.

2. Previous treatment with rat sarcoma (RAS) targeting agents.

3. Symptomatic, untreated, or actively progressing known central nervous system (CNS)metastases.

4. Impaired cardiovascular function or clinically significant cardiac disease.

5. Mean QT interval corrected using Fridericia's formula (QTcF) >470 msec.

6. Females who are pregnant or breastfeeding.