Sleep health is a critical component of cardiovascular well-being, and poor sleep has
been linked with increased risk for all-cause mortality including cardiovascular disease
(CVD). Previous research suggested that inadequate duration and quality of sleep may
increase the risk for developing cardiovascular disease. Moreover, many individuals
within a population may have underlying, subclinical cardiovascular conditions, such as
hypertension and arterial stiffness, and these may risk progressing to advanced CVD when
coupled with poor sleep. Given that Singapore ranks as the third most sleep-deprived city
globally, understanding the relationship between sleep health and the prevalence and
progression of CVD becomes increasingly important for population health. In addition,
depression and psychological stress could also lead to poorer cardiovascular health. by
increasing blood cholesterol, blood sugar and blood pressure, and could also be directly
related to or arise as a result of poor sleep. Therefore, it is essential to assess the
relationship between CVD progression and sleep as a multidimensional construct with
overlapping components, including duration, timing, regularity, and efficiency, using
objectively collected data over multiple days.
Through the combination of objective sleep tracking through wearables with health
assessments conducted in the RESET study (registered with ClinicalTrials.gov under
NCT06211868), we will gain valuable insights into these dimensions of poor sleep and
wellbeing factors that are associated with poor cardiovascular health.
The investigators aim to examine following questions using a combination of objective
sleep tracking (Oura ring), smartphone-based questionnaires (EMA) and detailed health
data collected by the RESET study.
How are sleep patterns, in terms of duration, timing, efficiency and regularity,
associated with cardiovascular health outcomes and disease risk, at baseline and
follow-up ?
How are sleep patterns, in terms of duration, timing, efficiency and regularity,
associated with vascular aging patterns?
How are patterns of subjective wellbeing related to cardiovascular health, at
baseline and follow-up ?
Do sleep and subjective wellbeing measures relate on a day to day basis?
The investigators hypothesize that inadequate sleep duration, timing, and regularity will
be associated with increased cardiovascular risk at baseline and follow-up. Individuals
with irregular sleep duration and timing are expected to demonstrate higher arterial
stiffness and profiles indicative of early vascular aging. Additionally, participants
reporting poor subjective well-being are anticipated to experience poorer sleep quality,
which will further associate with increased cardiovascular risk.
