A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)

Inclusion Criteria:

• Has systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg (if DBP criteria alone is met, SBP must be ≥130 mmHg) at screening (Visit 1).

• Has SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg (if DBP criteria alone is met, SBP must be ≥130 mmHg) at week 0 (Visit 3).

• Untreated for hypertension, or on stable antihypertensive medications ≥ 30 daysprior to Visit 1.

• Have a body mass index (BMI) ≥ 25 kg/m².

Exclusion Criteria:

• Has SBP ≥170 mmHg and/or DBP ≥110 mmHg at Visit 1 or at Visit 3.

• Has known secondary causes of hypertension

• Have heart failure with reduced ejection fraction (HFrEF) diagnosis

• Have had any of the following conditions within 90 days prior to screening.

• hospitalization for hypertension or for congestive heart failure

• acute coronary syndrome or acute myocardial infarction, or

• cerebrovascular accident (stroke).

• Have type 1 diabetes (T1D)

• Have acute or chronic hepatitis, including a history of autoimmune hepatitis