Effect of Partially Hydrolyzed Formula With Synbiotics on Skin Barrier Function

Inclusion Criteria:

1. Written informed consent has been obtained from at least one parent or legallyacceptable representative (LAR), if applicable

2. Infant gestational age ≥ 37 completed weeks

3. Infant birth weight of ≥ 2.5 kg and ≤ 4.5 kg

4. Infant postnatal age ≤ 14 days (date of birth = day 0) at enrollment

5. Infant from singleton birth or infant from multiple births may if all birth siblingsare enrolled.

6. At least one biological parent or sibling has (or had) a medically diagnosed historyof allergy, based on response to a simple screening questionnaire

7. a. For the breastfed reference group only: infant is exclusively breastfed sincebirth with no intake of formula, and their parent(s) have the intention to continueexclusive breastfeeding until at least 4 months of age. or b. For the randomized formula-fed groups only: infant is exclusively orpredominantly formula-fed in the 24 hours prior to enrollment, with formula feedingrepresenting at least 75% of total daily feeds. The decision to introduce formulafeeding was independently made by the parents before enrollment.

8. Parents/LAR must be able to provide evidence of parental authority and identity.

9. Infant's parent(s)/LAR must understand the informed consent form and other studydocuments and are willing and able to fulfill the requirements of the studyprotocol.

Exclusion Criteria:

1. Infectious, metabolic, congenital, genetic, gastrointestinal illness or any othercondition (e.g., gastrointestinal surgery) that could impact oral feeding, growth orstudy outcomes.

2. Infants with special dietary needs other than standard infant formula (e.g.,extensively hydrolyzed formula, amino acid formula, special formula for metabolicdiseases) or requiring tube feeding.

3. Infant has already been diagnosed with allergy by a physician, including AD and/orcow's milk allergy.

4. Infant is currently participating or has previously participated in another clinicaltrial prior to enrollment.

5. Infant's parents or LARs have not reached legal age of majority (18 years).