Direct Ischemic Conditioning for Endovascular Recanalization for Anterior Large Vessel Occlusion (DICER-aLVO)

Last updated: April 15, 2025
Sponsor: General Hospital of Shenyang Military Region
Overall Status: Active - Recruiting

Phase

N/A

Condition

Thrombosis

Cardiac Ischemia

Blood Clots

Treatment

Direct Ischemic Conditioning C

Direct Ischemic Conditioning A

Direct Ischemic Conditioning B

Clinical Study ID

NCT06940128
Y(2025)096
  • Ages > 18
  • All Genders

Study Summary

Acute ischemic stroke (AIS) is the most common type of stroke, with high incidence rate and mortality. Endovascular therapy is currently the most effective treatment for AIS with large vessel occlusion, but only about 50% of patients achieve good outcome after endovascular therapy, while 50% of patients have poor prognosis, commonly referred to as ineffective perfusion. Therefore, how to improve ineffective perfusion is currently a hot topic.

Numerous studies have shown that Remote Ischemic Therapy (RIC) has a protective effect on ischemic stroke. Our recent RICAMIS study has demonstrated that RIC can significantly improve the functional prognosis of moderate acute ischemic stroke. Furthermore, direct ischemic conditioning has also showed neuroprotective effect. For example, in a rat model, within 2 minutes after reperfusion, using three cycles of 30 s reperfusion and 10 s occlusion for direct ischemic conditioning can effectively alleviate hyperperfusion and reduce cerebral infarction volume. Meanwhile, in previous clinical exploration studies, it was found that even induction by 5-minute ischemia and 5-minute reperfusion for up to 4 cycles is safe, feasible, and well tolerated for AIS patients receiving endovascular treatment. Immediate control of bilateral carotid artery blood flow after ischemia-reperfusion can significantly reduce cerebral infarction area and brain edema, and improve neurological function recovery in rats. Subsequent molecular mechanism studies have shown that direct ischemic conditioning can reduce the production of free radicals after cerebral ischemia-reperfusion, inhibit inflammatory reactions and cell apoptosis, downregulate the expression of signaling molecules mediating brain edema, promote Akt survival pathway, and improve the integrity of the blood-brain barrier, thereby exerting neuroprotective effects. Recent studies have also confirmed the safety and feasibility of direct ischemic conditioning for stroke patients achieving successful recanalization. More importantly, a recent cohort study has shown that direct ischemic conditioning can reduce infarct growth and brain edema after reperfusion in patients with AIS who have undergone thrombectomy for occlusion of large blood vessels in the anterior circulation, and improve prognosis after 90 days.

Based on the above discussion, this trial aims to evaluate the effectiveness and safety of direct ischemic conditioning for patients with AIS who have undergone thrombectomy for occlusion of large blood vessels in the anterior circulation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

-1. Over 18 years old; 2. The time from onset to randomization is less than 24 hours; 3. Patients with acute anterior artery occlusion and receiving successful recanalization (mTICI 2b-3) after endovascular treatment and with residual stenosis ≤ 50%; 4. Cerebral circulation time after successful recanalization: affected side ≤ healthy side; 5. PH2 hemorrhage was excluded by immediate postoperative CT examination; 6. Re-onset patients with first onset or past onset without sequelae such as limb paralysis should not affect the score of this NIHSS, and mRS Score of patients with past onset should be less than 2 points; 7. Signed informed consent by patient or their legally authorized representative.

Exclusion

Exclusion Criteria:

  1. Spherical enlargement of the lesion site twice or more; 2. Proximal residualstenosis >50% for patients with tandem lesions; 3. Intracranial hemorrhagicdiseases: cerebral hemorrhage, subarachnoid hemorrhage, etc.

  2. Chronic liver disease, liver and kidney insufficiency, elevated ALT or AST (greaterthan 2 times the upper limit of normal), elevated serum creatinine (greater than 1.5times the upper limit of normal) or dependent on kidney dialysis; 5. Women who arepregnant, have a pregnancy plan or are breastfeeding; 6. Combined with serious otherdiseases, life expectancy < 6 months; 7. Other conditions deemed inappropriate forparticipation in this study.

Study Design

Total Participants: 120
Treatment Group(s): 3
Primary Treatment: Direct Ischemic Conditioning C
Phase:
Study Start date:
March 31, 2025
Estimated Completion Date:
March 31, 2026

Connect with a study center

  • General Hospital of Northern Theater Command

    Shengyang, Liaoning 110016
    China

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.