Outcomes of Ablation of Unresectable Pancreatic Cancer Using the NanoKnife Irreversible Electroporation System-

Inclusion Criteria:

• > = 18 years of age

• Must be found to have locally advanced unresectable disease following standardchemotherapy ± radiotherapy as demonstrated with either CT/MRI imaging and surgicalevaluation, and not have taken any chemotherapy/radiotherapy within 5 weeks oftreatment with the NanoKnife IRE System

• Must have an INR < 1.5

• Are willing and able to comply with the protocol requirements

• Are able to comprehend and willing to sign an informed consent form

Exclusion Criteria:

• Creatinine > 2.0 mg/dL

• Any lab value with a grade 3 or 4 toxicity as defined by the CTCAE Version 5.0

• Inability to stop antiplatelet and coumadin therapy for 7 days prior to and 7 dayspost treatment with the NanoKnife System

• Tumor size not measurable

• Known history of contrast allergy that cannot be medically managed

• Known hypersensitivity to the metal in the electrodes (stainless steel 304L) thatcannot be medically managed

• Unable to be treated with a muscle blockade agent (e.g. pancuronium bromide,atracurium, cisatracurium, etc.)

• Women who are pregnant or currently breast feeding

• Women of childbearing potential who are not utilizing an acceptable method ofcontraception

• Have taken an investigational agent within 30 days of visit 1

• Have implanted cardiac pacemakers or defibrillators

• Have implanted electronic devices or implants with metal parts in the vicinity of alesion

• Have a history of epilepsy or cardiac arrhythmia (atrial or ventricularfibrillation)

• Have a recent history of myocardial infarction (within the past 2 months)

• Have Q-T intervals greater than 550 ms unless treated with an Accysync Model 72synchronization system controlling the NanoKnife system's output pulses

• Evidence of distant metastases of stage IV

• Have taken any chemotherapeutic agent within 5 weeks of treatment with the NanoKnifeIrreversible Electroporation (IRE) System

• Received non-conventional fractionation schedules, such as stereotactic radiation (5fractions or less) or received higher than 54 Gray (Gy) delivered conventionally