A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque Psoriasis

Last updated: June 20, 2025
Sponsor: Janssen Research & Development, LLC
Overall Status: Active - Recruiting

Phase

3

Condition

Rash

Psoriasis And Psoriatic Disorders

Warts

Treatment

JNJ-77242113

Ustekinumab

Matching Placebo to JNJ-77242113

Clinical Study ID

NCT06934226
77242113PSO3006
2024-515706-77-00
77242113PSO3006
  • Ages > 12
  • All Genders

Study Summary

The main purpose of this study is to assess how well JNJ-77242113 works when compared to placebo and ustekinumab in participants with moderate to severe plaque psoriasis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), prior tothe first administration of study intervention

  • Total body surface area (BSA) greater than or equal to (>=)10 percent (%) atscreening and baseline

  • Total psoriasis area and severity index (PASI) >=12 at screening and baseline

  • Total investigator global assessment (IGA) >=3 at screening and baseline

  • Candidate for phototherapy or systemic treatment for plaque psoriasis

Exclusion

Exclusion Criteria:

  • Nonplaque form of psoriasis (for example [e.g.], erythrodermic, guttate, orpustular)

  • Current drug-induced psoriasis (e.g., a new onset of psoriasis or an exacerbation ofpsoriasis from beta blockers, calcium channel blockers, or lithium)

  • Known allergies, hypersensitivity, or intolerance to JNJ-77242113, ustekinumab, orits excipients

  • Major surgical procedure within 8 weeks before screening, or will not have fullyrecovered from surgical procedure, or has a surgical procedure planned during thetime the participant is expected to participate in the study

  • Transplanted organ (with exception of a corneal transplant greater than [>] 12 weeksbefore the first administration of study intervention)

Study Design

Total Participants: 675
Treatment Group(s): 4
Primary Treatment: JNJ-77242113
Phase: 3
Study Start date:
April 15, 2025
Estimated Completion Date:
December 29, 2027

Connect with a study center

  • Consultora Integral de Salud SRL

    Barrio Gral Paz Cba Capital, X5000
    Argentina

    Active - Recruiting

  • Instituto Medico De Alta Complejidad (IMAC)

    Buenos Aires, B1643CRO
    Argentina

    Active - Recruiting

  • Instituto de Neumonologia y Dermatologia

    Buenos Aires, C1425
    Argentina

    Active - Recruiting

  • Mindout Research

    Buenos Aires, C1417EYG
    Argentina

    Active - Recruiting

  • Buenos Aires Skin

    Caba, C1055AAO
    Argentina

    Active - Recruiting

  • CIPREC

    Caba, C1061AAS
    Argentina

    Active - Recruiting

  • Halitus Instituto Medico S.A. - Dermatologia y Estetica

    Caba, C1122AAF
    Argentina

    Active - Recruiting

  • Hospital Italiano de Buenos Aires

    Caba, C1199ABB
    Argentina

    Active - Recruiting

  • Investigaciones Medicas IMOBA SRL

    Caba, C1056ABH
    Argentina

    Active - Recruiting

  • Mautalen Salud e Investigacion

    Caba, C1128
    Argentina

    Active - Recruiting

  • Instituto De Especialidades De La Salud SRL

    Rosario, S2000DBS
    Argentina

    Active - Recruiting

  • MR Medicina Reumatologica

    San Fernando, B1646
    Argentina

    Active - Recruiting

  • Instituto de Investigaciones Medicas Tucuman

    Tucuman, T4000
    Argentina

    Active - Recruiting

  • Monash Medical Centre

    Clayton, 3168
    Australia

    Active - Recruiting

  • Cornerstone Dermatology

    Coorparoo, 4151
    Australia

    Active - Recruiting

  • Premier Specialists

    Kogarah, 2217
    Australia

    Active - Recruiting

  • Royal Melbourne Hospital

    Melbourne, 3050
    Australia

    Active - Recruiting

  • The Alfred Hospital

    Melbourne, 3004
    Australia

    Active - Recruiting

  • ISHI dermatology

    Mitcham, 3132
    Australia

    Active - Recruiting

  • Westmead Hospital

    Westmead, 2145
    Australia

    Active - Recruiting

  • Veracity Clinical Research

    Woolloongabba, 4102
    Australia

    Active - Recruiting

  • LKH Feldkirch

    Feldkirch, 6800
    Austria

    Active - Recruiting

  • Kepler Universitatsklinikum GmbH

    Linz, 4020
    Austria

    Active - Recruiting

  • Universtitatsklinikum St Polten

    Sankt Polten, 3100
    Austria

    Active - Recruiting

  • Allgemeines Krankenhaus der Stadt Wien

    Wien, 1090
    Austria

    Active - Recruiting

  • UZ Brussel

    Brussel, 1090
    Belgium

    Active - Recruiting

  • AZ St. Lucas

    Gent, 9000
    Belgium

    Active - Recruiting

  • Ghent University Hospital

    Ghent, 9000
    Belgium

    Active - Recruiting

  • Universitair Ziekenhuis Leuven

    Leuven, 3000
    Belgium

    Active - Recruiting

  • Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman

    Liege, 4000
    Belgium

    Active - Recruiting

  • Dermatologie Maldegem

    Maldegem, 9990
    Belgium

    Active - Recruiting

  • Skincare Studio Inc Dermatology Clinical Trials

    St Johns, Newfoundland and Labrador A1E 1V4
    Canada

    Active - Recruiting

  • CCA Medical Research Corporation

    Ajax, Ontario L1S7K8
    Canada

    Active - Recruiting

  • SimcoDerm Medical and Surgical Dermatology Centre

    Barrie, Ontario L4M 7G1
    Canada

    Active - Recruiting

  • Dermatrials Research

    Hamilton, Ontario L8N 1Y2
    Canada

    Active - Recruiting

  • Lovegrove Dermatology

    London, Ontario N6A 5R9
    Canada

    Active - Recruiting

  • Lynderm Research Inc.

    Markham, Ontario L3P 1X3
    Canada

    Active - Recruiting

  • Alliance Clinical Trials

    Waterloo, Ontario N2J 1C4
    Canada

    Active - Recruiting

  • Innovaderm Research Inc.

    Montreal, Quebec H2X 2V1
    Canada

    Active - Recruiting

  • The Centre de recherche Saint-Louis

    Quebec, G1W 4R4
    Canada

    Active - Recruiting

  • Aalborg Sygehus Syd

    Aalborg, 9100
    Denmark

    Active - Recruiting

  • Aarhus University Hospital

    Aarhus, 8200
    Denmark

    Active - Recruiting

  • Gentofte Hospital

    Hellerup, 2900
    Denmark

    Active - Recruiting

  • Bispebjerg Hospital

    Kobenhavn NV, 2400
    Denmark

    Active - Recruiting

  • Odense University Hospital

    Odense, 5000
    Denmark

    Active - Recruiting

  • Sjællands University hospital

    Roskilde, 4000
    Denmark

    Active - Recruiting

  • Klinikum Augsburg

    Augsburg, 86179
    Germany

    Active - Recruiting

  • Fachklinik Bad Bentheim

    Bad Bentheim, 48455
    Germany

    Active - Recruiting

  • ISA - Interdisciplinary Study Association GmbH

    Berlin, 10789
    Germany

    Active - Recruiting

  • Universitatsklinikum Bonn

    Bonn, 53127
    Germany

    Active - Recruiting

  • Studienzentrum an der Hase GbR

    Bramsche, 49565
    Germany

    Active - Recruiting

  • Rosenpark Research GmbH

    Darmstadt, 64283
    Germany

    Active - Recruiting

  • Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden

    Dresden, 01307
    Germany

    Active - Recruiting

  • Derma-Study-Center Friedrichshafen GmbH

    Friedrichshafen, 88045
    Germany

    Active - Recruiting

  • Universitaetsklinikum Schleswig Holstein Campus Kiel

    Kiel, 24105
    Germany

    Active - Recruiting

  • Studienzentrum Dr Schwarz Germany

    Langenau, 89129
    Germany

    Active - Recruiting

  • Dermatologie Mahlow

    Mahlow, 15831
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis Dres. Quist

    Mainz, 55128
    Germany

    Active - Recruiting

  • Universitaetsklinikum Muenster

    Muenster, 48149
    Germany

    Active - Recruiting

  • Hautarztpraxis

    Witten, 58453
    Germany

    Active - Recruiting

  • Obudai Egeszsegugyi Centrum Kft

    Budapest, 1036
    Hungary

    Active - Recruiting

  • Uno Medical Trials Ltd.

    Budapest, 1152
    Hungary

    Active - Recruiting

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032
    Hungary

    Active - Recruiting

  • Derma-B Kft

    Debrecen, 4031
    Hungary

    Active - Recruiting

  • Gyongyosi Bugat Pal Korhaz

    Gyongyos, 3200
    Hungary

    Active - Recruiting

  • Synexus Magyarorszag Kft

    Gyula, 5700
    Hungary

    Active - Recruiting

  • Porcika Klinika - Vasarhelyi Sarkanyfu Kft.

    Hodmezovasarhely, 6800
    Hungary

    Active - Recruiting

  • Somogy Varmegyei Kaposi Mor Oktato Korhaz

    Kaposvar, 7400
    Hungary

    Active - Recruiting

  • Bacs-kiskun Megyei Korhaz

    Kecskemet, 6000
    Hungary

    Active - Recruiting

  • Allergo-Derm Bakos Kft.

    Szolnok, 5000
    Hungary

    Active - Recruiting

  • Medmare Egeszsegugyi Es Szolgaltato Bt.

    Veszprem, 8200
    Hungary

    Active - Recruiting

  • Osteo-Medic s.c A. Racewicz, J Supronik

    Bialystok, 15 351
    Poland

    Active - Recruiting

  • Specderm Poznanska sp j

    Bialystok, 15 375
    Poland

    Active - Recruiting

  • Centrum Kliniczno Badawcze J Brzezicki B Gornikiewicz Brzezicka Lekarze Spolka Partnerska

    Elblag, 82 300
    Poland

    Active - Recruiting

  • Care Clinic Sp z o o

    Katowice, 40 568
    Poland

    Active - Recruiting

  • Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna

    Krakow, 30 002
    Poland

    Active - Recruiting

  • Dermed Centrum Medyczne Sp z o o

    Lodz, 90 265
    Poland

    Active - Recruiting

  • Etyka Osrodek Badan Klinicznych Tomasz Pesta S K A

    Olsztyn, 10 117
    Poland

    Active - Recruiting

  • SOLUMED Centrum Medyczne

    Poznan, 60 529
    Poland

    Active - Recruiting

  • Velocity Skierniewice sp z o o

    Skierniewice, 96 100
    Poland

    Active - Recruiting

  • Klinika Ambroziak Dermatologia

    Warszawa, 02 953
    Poland

    Active - Recruiting

  • Magdalena Opadczuk Carpe Diem Centrum Medycyny Estetycznej

    Warszawa, 02 661
    Poland

    Active - Recruiting

  • Centrum Medyczne Oporow

    Wroclaw, 52 416
    Poland

    Active - Recruiting

  • WroMedica

    Wroclaw, 51 685
    Poland

    Active - Recruiting

  • Uls Alto Ave - Hosp. Sra. Da Oliveira Guimaraes

    Braga, 4835 044
    Portugal

    Active - Recruiting

  • Unidade Local De Saude Da Regiao De Leiria Epe

    Leiria, 2410 197
    Portugal

    Active - Recruiting

  • Hosp. Cuf Descobertas

    Lisboa, 1998 018
    Portugal

    Active - Recruiting

  • Uls Sao Jose - Hosp. Sto Antonio Dos Capuchos

    Lisboa, 1169 050
    Portugal

    Active - Recruiting

  • Ulssa Hosp. Santo Antonio

    Porto, 4099 001
    Portugal

    Active - Recruiting

  • Hosp. Gral. Univ. Dr. Balmis

    Alicante, 03010
    Spain

    Active - Recruiting

  • Hosp. Univ. de Cruces

    Barakaldo, 48902
    Spain

    Active - Recruiting

  • Hosp. Clinic de Barcelona

    Barcelona, 08036
    Spain

    Active - Recruiting

  • Hosp. Univ. San Cecilio

    Granada, 18016
    Spain

    Active - Recruiting

  • Grupo Dermatologico Y Estetico Pedro Jaen

    Madrid, 28006
    Spain

    Active - Recruiting

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041
    Spain

    Active - Recruiting

  • Hosp. Univ. de La Princesa

    Madrid, 28006
    Spain

    Active - Recruiting

  • Hosp. de Manises

    Manises, 46940
    Spain

    Active - Recruiting

  • Hosp. Clinico Univ. de Santiago

    Santiago Compostela, 15706
    Spain

    Active - Recruiting

  • Hosp. Ntra. Sra. de Valme

    Sevilla, 41014
    Spain

    Active - Recruiting

  • Hosp. Virgen Macarena

    Sevilla, 41009
    Spain

    Active - Recruiting

  • Hosp. Univ. I Politecni La Fe

    Valencia, 46026
    Spain

    Active - Recruiting

  • Hosp. de La Marina Baixa

    Villajoyosa, 03570
    Spain

    Active - Recruiting

  • Hosp. Clinico Univ. Lozano Blesa

    Zaragoza, 50009
    Spain

    Active - Recruiting

  • Hosp. Univ. Miguel Servet

    Zaragoza, 50009
    Spain

    Active - Recruiting

  • Dudley Group NHS Foundation Trust

    Dudley, DY1 2HQ
    United Kingdom

    Active - Recruiting

  • London North West University Healthcare NHS Trust

    Harrow, HA1 3UJ
    United Kingdom

    Active - Recruiting

  • The Queen Elizabeth Hospital NHS Foundation Trust

    Kings Lynn, PE30 4ET
    United Kingdom

    Active - Recruiting

  • Guys and St Thomas NHS Foundation Trust

    London, SE1 9RT
    United Kingdom

    Active - Recruiting

  • Royal Berkshire Hospital

    Reading, RG1 5AN
    United Kingdom

    Active - Recruiting

  • Salford Royal Hospital

    Salford, M6 8HD
    United Kingdom

    Active - Recruiting

  • University Hospital Southampton

    Southampton, So166yd
    United Kingdom

    Active - Recruiting

  • Mid Yorkshire NHS Trust

    Wakefield, WF1 4DG
    United Kingdom

    Active - Recruiting

  • Cahaba Research Inc

    Birmingham, Alabama 35244
    United States

    Active - Recruiting

  • California Dermatology & Clinical Research Institute

    Encinitas, California 92024
    United States

    Active - Recruiting

  • T Joseph Raoof Md Inc

    Encino, California 91436
    United States

    Active - Recruiting

  • First OC Dermatology

    Fountain Valley, California 92708
    United States

    Active - Recruiting

  • Dermatologist Medical Group of North County, Inc.

    Oceanside, California 92056
    United States

    Active - Recruiting

  • NorCal Clinical Research

    Rocklin, California 95765
    United States

    Active - Recruiting

  • Integrative Skin Science and Research

    Sacramento, California 95815
    United States

    Active - Recruiting

  • MedDerm Associates

    San Diego, California 92103
    United States

    Active - Recruiting

  • Southern California Dermatology

    Santa Ana, California 92701
    United States

    Active - Recruiting

  • Olive View-UCLA Education & Research Institute

    Sylmar, California 91342
    United States

    Active - Recruiting

  • University of Conn Health Center

    Farmington, Connecticut 06030
    United States

    Active - Recruiting

  • Driven Research LLC

    Coral Gables, Florida 33134
    United States

    Active - Recruiting

  • Bioclinical Research Alliance Inc.

    Miami, Florida 33155
    United States

    Active - Recruiting

  • Renstar Medical Research

    Ocala, Florida 34470
    United States

    Active - Recruiting

  • Forcare Clinical Research Inc

    Tampa, Florida 33613
    United States

    Active - Recruiting

  • Hamilton Research LLC

    Alpharetta, Georgia 30022
    United States

    Active - Recruiting

  • Northshore Medical Group

    Skokie, Illinois 60076
    United States

    Active - Recruiting

  • Indiana Clinical Trial Center

    Plainfield, Indiana 46168
    United States

    Active - Recruiting

  • University of Iowa

    Iowa City, Iowa 52242
    United States

    Active - Recruiting

  • Equity Medical

    Bowling Green, Kentucky 42104
    United States

    Active - Recruiting

  • Tufts Medical Center

    Boston, Massachusetts 02111
    United States

    Active - Recruiting

  • Metro Boston Clinical Partners

    Brighton, Massachusetts 02135
    United States

    Active - Recruiting

  • The Derm Institute of West Michigan

    Caledonia, Michigan 49316
    United States

    Active - Recruiting

  • Henry Ford Hospital

    Detroit, Michigan 48202
    United States

    Active - Recruiting

  • Hamzavi Dermatology

    Fort Gratiot, Michigan 48059
    United States

    Active - Recruiting

  • Somerset Skin Centre

    Troy, Michigan 48084
    United States

    Active - Recruiting

  • Minnesota Clinical Study Center

    New Brighton, Minnesota 55112
    United States

    Active - Recruiting

  • Cleaver Dermatology

    Kirksville, Missouri 63501
    United States

    Active - Recruiting

  • MediSearch Clinical Trials

    Saint Joseph, Missouri 64506
    United States

    Active - Recruiting

  • Mount Sinai Doctors Dermatology

    New York, New York 10028
    United States

    Active - Recruiting

  • Sadick Research Group

    New York, New York 10075
    United States

    Active - Recruiting

  • Wilmington Dermatology Center

    Wilmington, North Carolina 28405
    United States

    Active - Recruiting

  • Optima Research

    Boardman, Ohio 44512
    United States

    Active - Recruiting

  • Apex Dermatology Mayfield Heights

    Mayfield Heights, Ohio 44124
    United States

    Active - Recruiting

  • Oregon Dermatology and Research Center

    Portland, Oregon 97210
    United States

    Active - Recruiting

  • Oregon Medical Research Center

    Portland, Oregon 97201
    United States

    Active - Recruiting

  • Clinical Research Philadelphia

    Philadelphia, Pennsylvania 19114
    United States

    Active - Recruiting

  • UPMC Department of Dermatology

    Pittsburgh, Pennsylvania 15213
    United States

    Active - Recruiting

  • Health Concepts

    Rapid City, South Dakota 57702
    United States

    Active - Recruiting

  • Advanced Research Experts PLLC

    Nashville, Tennessee 37211
    United States

    Active - Recruiting

  • Arlington Research Center, Inc.

    Arlington, Texas 76011
    United States

    Active - Recruiting

  • Modern Research Associates PLLC

    Dallas, Texas 75231
    United States

    Active - Recruiting

  • Center for Clinical Studies

    Houston, Texas 77004
    United States

    Active - Recruiting

  • Progressive Clinical Research

    San Antonio, Texas 78213
    United States

    Active - Recruiting

  • Texas Dermatology and Laser Specialists

    San Antonio, Texas 78218
    United States

    Active - Recruiting

  • Center for Clinical Studies

    Webster, Texas 77598
    United States

    Active - Recruiting

  • Kalo Clinical Research

    West Valley City, Utah 84120
    United States

    Active - Recruiting

  • Frontier Derm Partners CRO, LLC

    Mill Creek, Washington 98012
    United States

    Active - Recruiting

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