MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes

Last updated: September 22, 2025
Sponsor: Medical College of Wisconsin
Overall Status: Active - Recruiting

Phase

2

Condition

Stroke

Cerebral Ischemia

Occlusions

Treatment

Ischemic Conditioning

Antioxidant Supplement

Clinical Study ID

NCT06930638
PRO00054821
  • Ages 18-85
  • All Genders

Study Summary

Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance. Preliminary data shows a single bout of ischemic conditioning or oral ingestion of an over-the-counter antioxidant supplement called MitoQ may improve vascular function and muscle activity in individuals post-stroke.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18 - 85 years of age

  • Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis

  • Able to give informed consent and follow 2-step command.

  • English Speaking

Exclusion

Exclusion Criteria:

  • Unable to stand from chair without physical assistance from another person (able touse assistive device).

  • History of blood clots in the extremities or any condition in which compression ofthe thigh or transient ischemia is contraindicated (i.e., wounds in the leg).

  • Chronic lasting symptoms (> 6 months) of severe COVID-19 (i.e., hospitalization)

  • History of head trauma or concussion within the past 6 months

  • Comorbid neurological disorder

  • Peripheral vascular disease

  • Myocardial infarction or arrhythmia in the previous year

  • Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg

  • Pregnant or breastfeeding.

  • Other significant medical condition likely to influence study or jeopardize safetyas assessed by the Primary Investigator

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: Ischemic Conditioning
Phase: 2
Study Start date:
July 22, 2025
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Medical College of Wisconsin

    Milwaukee 5263045, Wisconsin 5279468 53226
    United States

    Active - Recruiting

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