Genicular Artery Embolization (GAE) vs inTra-articular Corticosteroid Injection for Osteoarthritic Knee Pain.

Last updated: April 8, 2025
Sponsor: National Taiwan University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Osteoarthritis

Treatment

Genicular artery embolization

Intra-articular injection with corticosteroids.

Clinical Study ID

NCT06929585
202408153RIND
  • Ages > 40
  • All Genders

Study Summary

This study investigates genicular artery embolization (GAE) as a minimally invasive alternative to ntra-articular corticosteroid injections (IA) or treating knee osteoarthritis (OA) pain. Designed as a randomized controlled tria, the study compares pain relief effectiveness and safety between GAE and IA over a 12-month follow-up. Eligible participants are aged over 40 with symptomatic knee OA resistant to conservative treatment. Primary outcomes focus on pain reduction (NRS score), while secondary measures include function, quality of life, imaging findings, and adverse events.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age ≥ 40 years

  2. Symptomatic knee pain, with numeric rating scale (NRS) ≥ 4.

  3. Insufficient or resistant to conservative treatment, including oral analgesics,physical therapy, intra-articular injections for at least 3 months, before theenrollment.

  4. Weight bearing X ray of knee: osteoarthritis of Kellgren-Lawrence grade 1, 2, or 3.

Exclusion

Exclusion Criteria:

  1. History of trauma in recent 6 months.

  2. Bleeding tendency.

  3. Poor renal function (serum creatinine > 2.0 mg/dL).

  4. Pregnancy or breast-feeding.

  5. Severe peripheral arterial occlusive disease (PAOD).

  6. Local infections or inflammatory arthritis of knee.

  7. Rheumatoid arthritis or other rheumatological diseases.

  8. Prior knee surgeries (arthroscopic surgery, menisci repair, cruciate ligamentreconstruction, arthroplasty of knee) due to knee pain.

  9. Malignancy

  10. ECOG > grade 2

  11. Life expectancy less than 2 years.

  12. Any other condition related to the patient's health, regarded exclusionary in theopinion of the investigator.

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Genicular artery embolization
Phase:
Study Start date:
March 25, 2025
Estimated Completion Date:
December 31, 2028

Connect with a study center

  • National Taiwan University Hosiptal Yunlin Branch

    Douliu, Yunlin 640
    Taiwan

    Active - Recruiting

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