A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)

Last updated: December 3, 2025
Sponsor: Merck Sharp & Dohme LLC
Overall Status: Active - Not Recruiting

Phase

2

Condition

Vascular Diseases

Stress

Williams Syndrome

Treatment

Sotatercept

Background PAH Therapy

Clinical Study ID

NCT06925750
7962-031
jRCT2061250021
U1111-1314-0614
MK-7962-031
2024-518687-12
2024-518687-12-00
  • Ages > 18
  • All Genders

Study Summary

Researchers are looking for other ways to treat pulmonary arterial hypertension (PAH). Sotatercept is a study medicine that is designed to treat PAH.

A past study, MK-7962-024 (LIGHTRAY) (NCT06664801), learned about the safety and effects of sotatercept in people with PAH. One of the goals of that study was to learn about sotatercept when given at a dose (amount) based on the weight range a person is in (weight-banded doses) compared to when given based on a person's exact weight.

This is an extension study, which means people who took part in MK-7962-024 (LIGHTRAY) may be able to join this study. In this extension study, people will get weight-banded doses of sotatercept. The main goal of this study is to learn about the safety of weight-banded doses of sotatercept and if people tolerate it over a longer period of time.

Eligibility Criteria

Inclusion

Inclusion Criteria:

The main inclusion criteria include but are not limited to the following:

  • Has completed the treatment period of study MK-7962-024 (LIGHTRAY) (including Visit
  1. on study intervention, did not discontinue study intervention, and is able tosafely enroll into MK-7962-031 (LIGHTRAY EXTENSION)
  • Has not started treatment with commercially available sotatercept

Exclusion

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following:

  • Has current exposure or is planning to begin treatment with an activin signaling inhibitor (other than sotatercept)

Study Design

Total Participants: 130
Treatment Group(s): 2
Primary Treatment: Sotatercept
Phase: 2
Study Start date:
May 12, 2025
Estimated Completion Date:
June 16, 2028

Connect with a study center

  • Centro Medico Capital ( Site 0002)

    La Plata 3432043, Buenos Aires 3435907 B1904AAW
    Argentina

    Site Not Available

  • Instituto de Investigaciones Clinicas Mar del Plata ( Site 0006)

    Mar del Plata 3430863, Buenos Aires 3435907 B7600FZO
    Argentina

    Site Not Available

  • Instituto Medico Rio Cuarto ( Site 0010)

    Río Cuarto 3838874, Córdoba Province 3860255 X5800AEV
    Argentina

    Site Not Available

  • Instituto de Cardiologia Juana F. Cabral ( Site 0008)

    Corrientes 3435217, W3400AMZ
    Argentina

    Site Not Available

  • Hospital Provincial Jose Maria Cullen ( Site 0005)

    Santa Fe 3836277, S3000EOM
    Argentina

    Site Not Available

  • Royal Prince Alfred Hospital ( Site 0103)

    Camperdown 2172563, New South Wales 2155400 2050
    Australia

    Site Not Available

  • Westmead Hospital ( Site 0100)

    Westmead 2143973, New South Wales 2155400 2145
    Australia

    Site Not Available

  • Wesley Research Institute ( Site 0101)

    Auchenflower 6943571, Queensland 2152274 4066
    Australia

    Site Not Available

  • The Alfred Hospital ( Site 0102)

    Melbourne 2158177, Victoria 2145234 3004
    Australia

    Site Not Available

  • IUCPQ ( Site 0208)

    Québec 6325494, Quebec 6115047 G1V 4G5
    Canada

    Site Not Available

  • Guangdong Provincial People's Hospital-Cardiology ( Site 2000)

    Guangzhou, Guangdong 510080
    China

    Site Not Available

  • Guangdong Provincial People's Hospital-Cardiology ( Site 2000)

    Guangzhou 1809858, Guangdong 1809935 510080
    China

    Site Not Available

  • The Second Xiangya Hospital of Central South University ( Site 2002)

    Changsha 1815577, Hunan 1806691 410011
    China

    Site Not Available

  • Shanghai Pulmonary Hospital ( Site 2004)

    Shanghai 1796236, Shanghai Municipality 1796231 200433
    China

    Site Not Available

  • Yan an Hospital of Kunming City ( Site 2011)

    Kunming 1804651, Yunnan 1785694 650051
    China

    Site Not Available

  • Clinica Colsanitas - Sede Reina Sofia ( Site 0303)

    Bogotá 3688689, Bogota D.C. 3688685 110111
    Colombia

    Site Not Available

  • Fundacion Santa Fe de Bogota ( Site 0302)

    Bogotá 3688689, Bogota D.C. 3688685 110111
    Colombia

    Site Not Available

  • IMAT S.A.S ( Site 0301)

    Montería 3674453, Departamento de Córdoba 3685889 230002
    Colombia

    Site Not Available

  • Centro de Investigaciones Clinicas SAS ( Site 0306)

    Cali, Valle Del Cauca 760036
    Colombia

    Site Not Available

  • Clínica Imbanaco S.A.S ( Site 0304)

    Cali 3687925, Valle del Cauca Department 3666313 760042
    Colombia

    Site Not Available

  • Clínica Imbanaco S.A.S ( Site 0304)

    Santiago de Cali 3687925, Valle del Cauca Department 3666313 760042
    Colombia

    Site Not Available

  • Vseobecna fakultni nemocnice v Praze ( Site 0400)

    Prague 3067696, Praha 2 128 08
    Czechia

    Site Not Available

  • CHU Bordeaux Haut-Leveque ( Site 0501)

    Pessac 2987805, Aquitaine 33600
    France

    Site Not Available

  • C.H.U Hôpital Nord ( Site 0500)

    Marseille 2995469, Bouches-du-Rhone 13015
    France

    Site Not Available

  • CHU de Rouen ( Site 0503)

    Rouen 2982652, Haute-Normandie 76000
    France

    Site Not Available

  • CHU GABRIEL MONTPIED ( Site 0504)

    Clermont-Ferrand 3024635, Puy-de-Dome 63000
    France

    Site Not Available

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Családorvosi Intézet és Rendelő ( Site 0704)

    Szeged 715429, Csongrád megye 721589 6725
    Hungary

    Site Not Available

  • Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 0702)

    Budapest, Pest County 3046431 1096
    Hungary

    Site Not Available

  • Semmelweis Egyetem ( Site 0701)

    Budapest, Pest County 3046431 1083
    Hungary

    Site Not Available

  • Carmel Hospital ( Site 0803)

    Haifa 294801, 3436212
    Israel

    Site Not Available

  • Rambam Health Care Campus ( Site 0802)

    Haifa 294801, 3109601
    Israel

    Site Not Available

  • Rabin Medical Center ( Site 0805)

    Petah Tikva 293918, 4941492
    Israel

    Site Not Available

  • Sheba Medical Center ( Site 0801)

    Ramat Gan 293788, 5265601
    Israel

    Site Not Available

  • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico ( Site 0902)

    Milan 3173435, Lombardy 3174618 20122
    Italy

    Site Not Available

  • Azienda Ospedaliera Universitaria Integrata ( Site 0908)

    Verona 3164527, Veneto 3164604 37126
    Italy

    Site Not Available

  • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 0905)

    Bologna 3181928, 40139
    Italy

    Site Not Available

  • Ospedale San Martino ( Site 0901)

    Genova 8969657, 16132
    Italy

    Site Not Available

  • Fondazione IRCCS Policlinico San Matteo ( Site 0909)

    Pavia 3171366, 27100
    Italy

    Site Not Available

  • AOU Policlinico Umberto I ( Site 0910)

    Roma 8957247, 00161
    Italy

    Site Not Available

  • Ospedale Civile SS Annunziata ( Site 0903)

    Sassari 3167096, 07100
    Italy

    Site Not Available

  • Nagoya University Hospital ( Site 2102)

    Nagoya 1856057, Aichi-ken 1865694 466-8560
    Japan

    Site Not Available

  • National Cerebral and Cardiovascular Center ( Site 2103)

    Suita 1851483, Osaka 1853904 564-8565
    Japan

    Site Not Available

  • The University of Tokyo Hospital ( Site 2101)

    Bunkyo, Tokyo 1850144 113-8655
    Japan

    Site Not Available

  • Kyorin University Hospital ( Site 2100)

    Mitaka 11790343, Tokyo 1850144 181-8611
    Japan

    Site Not Available

  • Kyushu University Hospital ( Site 2105)

    Fukuoka 1863967, 812-8582
    Japan

    Site Not Available

  • National Hospital Organization Okayama Medical Center ( Site 2104)

    Okayama, 701-1192
    Japan

    Site Not Available

  • National Hospital Organization Okayama Medical Center ( Site 2104)

    Okayama 1854383, 701-1192
    Japan

    Site Not Available

  • Radboud University Medical Center ( Site 1001)

    Nijmegen, Gelderland 6525 GA
    Netherlands

    Site Not Available

  • Radboud University Medical Center ( Site 1001)

    Nijmegen 2750053, Gelderland 2755634 6525 GA
    Netherlands

    Site Not Available

  • Sint Antonius Ziekenhuis ( Site 1000)

    Nieuwegein 2750325, Utrecht 2745909 3435CM
    Netherlands

    Site Not Available

  • National University Heart Centre, Singapore ( Site 1200)

    Singapore, Central Singapore 119074
    Singapore

    Site Not Available

  • National Heart Centre Singapore ( Site 1201)

    Singapore 1880252, Central Singapore 169609
    Singapore

    Site Not Available

  • National University Heart Centre, Singapore ( Site 1200)

    Singapore 1880252, Central Singapore 119074
    Singapore

    Site Not Available

  • Chonnam National University Hospital ( Site 1304)

    Gwangju 1841811, Kwangju-Kwangyokshi 61469
    South Korea

    Site Not Available

  • Pusan National University Hospital ( Site 1305)

    Seogu 10354426, Pusan-Kwangyokshi 49241
    South Korea

    Site Not Available

  • Asan Medical Center ( Site 1303)

    Seoul 1835848, 05505
    South Korea

    Site Not Available

  • Samsung Medical Center ( Site 1301)

    Seoul 1835848, 06351
    South Korea

    Site Not Available

  • Seoul National University Hospital ( Site 1302)

    Seoul 1835848, 03080
    South Korea

    Site Not Available

  • Severance Hospital Yonsei University Health System ( Site 1300)

    Seoul 1835848, 03722
    South Korea

    Site Not Available

  • Hospital Universitari Son Espases ( Site 1412)

    Palma, Baleares 07120
    Spain

    Site Not Available

  • Hospital Universitari Son Espases ( Site 1412)

    Palma 2512989, Balearic Islands 2521383 07120
    Spain

    Site Not Available

  • Hospital Universitario Marqués de Valdecilla ( Site 1405)

    Santander 3109718, Cantabria 3336898 39008
    Spain

    Site Not Available

  • Hospital Clinic de Barcelona ( Site 1406)

    Barcelona 3128760, Catalonia 3336901 08036
    Spain

    Site Not Available

  • Hospital Universitari Vall d''Hebron ( Site 1404)

    Barcelona 3128760, 08035
    Spain

    Site Not Available

  • Hospital Universitario 12 de Octubre ( Site 1403)

    Madrid, 28041
    Spain

    Site Not Available

  • Hospital Universitario 12 de Octubre ( Site 1403)

    Madrid 3117735, 28041
    Spain

    Site Not Available

  • Hospital Universitario La Paz ( Site 1410)

    Madrid 3117735, 28046
    Spain

    Site Not Available

  • Hospital Universitario Virgen del Rocio ( Site 1407)

    Seville 2510911, 41013
    Spain

    Site Not Available

  • HOSPITAL GENERAL UNIVERSITARIO DE TOLEDO ( Site 1408)

    Toledo 2510409, 45007
    Spain

    Site Not Available

  • National Cheng Kung University Hospital ( Site 1501)

    Tainan 1668355, 704302
    Taiwan

    Site Not Available

  • National Cheng Kung University Hospital ( Site 1501)

    Tainan City 1668355, 704302
    Taiwan

    Site Not Available

  • Taipei Veterans General Hospital ( Site 1502)

    Taipei, 112201
    Taiwan

    Site Not Available

  • Taipei Veterans General Hospital ( Site 1502)

    Taipei 1668341, 112201
    Taiwan

    Site Not Available

  • Faculty of Medicine Siriraj Hospital ( Site 1600)

    Bangkoknoi, Bangkok 1609348 10700
    Thailand

    Site Not Available

  • Maharaj Nakorn Chiang Mai Hospital ( Site 1601)

    Muang, Chiang Mai 1153670 50200
    Thailand

    Site Not Available

  • Royal Papworth Hospital ( Site 1802)

    Cambridge 2653941, Cambridgeshire CB2 0AY
    United Kingdom

    Site Not Available

  • Royal Free Hospital ( Site 1803)

    London 2643743, England 6269131 NW3 2QG
    United Kingdom

    Site Not Available

  • Hammersmith Hospital ( Site 1801)

    London, London, City Of W12 OHS
    United Kingdom

    Active - Recruiting

  • Royal Brompton Hospital ( Site 1804)

    London, London, City Of SW3 6HP
    United Kingdom

    Site Not Available

  • Hammersmith Hospital ( Site 1801)

    London 2643743, London, City of W12 OHS
    United Kingdom

    Site Not Available

  • Royal Brompton Hospital ( Site 1804)

    London 2643743, London, City of SW3 6HP
    United Kingdom

    Site Not Available

  • Golden Jubilee National Hospital ( Site 1800)

    Glasgow City, Scotland G81 4DY
    United Kingdom

    Site Not Available

  • Golden Jubilee National Hospital ( Site 1800)

    Glasgow 2648579, Scotland 2638360 G81 4DY
    United Kingdom

    Site Not Available

  • University of Colorado Anschutz Medical Campus-University of Colorado Hospital Cardiac and Vascular ( Site 1930)

    Aurora 5412347, Colorado 5417618 80045
    United States

    Site Not Available

  • University of Kansas Medical Center ( Site 1928)

    Kansas City 4273837, Kansas 4273857 66160
    United States

    Site Not Available

  • University of New Mexico Health Sciences Center - Department of Internal Medicine ( Site 1916)

    Albuquerque 5454711, New Mexico 5481136 87131
    United States

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.