A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome Patients

Inclusion Criteria:

1. Adult aged from 18 years

2. Patients electively treated for rectal cancer with a low anterior resection

3. Between 3 and 18 months after the conservative colorectal surgery or 3 and 18 monthsafter the stoma reversal if applicable

4. LARS score >= 25 (minor or major LARS) (Emmertsen and Laurberg 2012) AND LARSdefinition as consensus with at least one symptom that results in at least oneconsequence (Keane et al. 2020)

5. Adult for whom previous conservative treatments were started for at least a month

6. Mental and physical capability of the patient to handle the MiniGo by himself.

7. Check of the anastomosis (no signs of leakage or clinical relevant stenosis) andabsence of local recurrence by Rectal digital examination of the anastomosis, anyother exam used in the current practice

8. Patient affiliated to the health social security system

Exclusion Criteria:

1. Contra-indication to use TAI

2. Former use of TAI (post colo-rectal surgery)

3. Clinically relevant stenosis

4. Current metastatic disease or local recurrence

5. Ongoing chemotherapy

6. Postoperative radiotherapy for rectal cancer

7. History of diarrhoeal disease

8. Inflammatory bowel disease

9. Dementia

10. Spinal cord injury, multiple sclerosis, Parkinson's disease or other significantdisease assessed to be a contributory cause to LARS symptoms.

11. Patient with cancer recurrence

12. Patient with a life expectancy < 1 year

13. Participating to another clinical trial for the treatment of LARS symptom

14. Ongoing pelvic floor rehabilitation/biofeedback

15. Pregnancy or intention to become pregnant during the trial period

16. Inability and unwillingness to give informed consent