Maternal Left Lateral Position in Fetal Growth Restriction

Last updated: July 14, 2025
Sponsor: University of Colorado, Denver
Overall Status: Active - Recruiting

Phase

N/A

Condition

Birth Defects

Treatment

Left lateral recumbent positioning

Clinical Study ID

NCT06919692
25-0289
  • Ages 18-65
  • Female

Study Summary

The goal of this clinical trial is to learn if maternal left-lateral positioning in pregnancy works to treat fetal growth restriction. This study will also help us learn about the effects of left-lateral positioning on maternal metabolomics, maternal mental health, fetal cardiac function, and delivery outcomes. The main questions it aims to answer are:

  • Does maternal left-lateral position in a pregnancy with fetal growth restriction improve the baby's growth?

  • How are maternal metabolomics, delivery outcomes, maternal mental health, and fetal cardiac function impacted by maternal left-lateral position? Researchers will compare the intervention group to pregnancies with fetal growth restriction that receive standard of care (without left-lateral positioning) to see if left-lateral position improves fetal biometry in fetal growth restriction.

Participants will:

  • Practice left-lateral position every day for 4 hours (cumulatively) with 10-mins stretching after every hour of left-lateral position, or continue to receive standard of care

  • Visit the clinic once after 4 weeks for a follow-up research visit, and at the time of delivery

Tracking of the physical activity and adherence to left-lateral position at home in intervention group A will be done through a fitbit (smart watch) given during enrollment. A fitbit will also be given to participants in intervention group B, receiving standard of care, to monitor their physical activity trends at home.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Pregnant persons between 18 - 65 years of age, with a diagnosis of fetal growthrestriction, with an estimated fetal weight less than tenth percentile

  • Participants with a singleton pregnancy between 24- and 34-weeks' gestational age

  • Participants with fluency in English or Spanish language

Exclusion

Exclusion Criteria:

  • Patients with a known history of deep vein thrombosis, pulmonary embolism, orhypercoagulability disorder

  • Patients with a pre-pregnancy BMI greater than 40

  • Pregnancy with severe abnormality in umbilical artery Doppler flow, including absentend-diastolic flow (AEDF) and reverse end-diastolic flow (REDF)

  • Patients receiving anticoagulation therapy

  • Pregnancy with suspected chromosomal anomalies or a multifetal pregnancy

  • Patients with an active smoking status during pregnancy

Study Design

Total Participants: 100
Treatment Group(s): 1
Primary Treatment: Left lateral recumbent positioning
Phase:
Study Start date:
July 28, 2025
Estimated Completion Date:
December 03, 2026

Connect with a study center

  • UCHealth Prenatal Diagnosis and Genetics Clinic - Anschutz Medical Campus

    Aurora, Colorado 80045
    United States

    Active - Recruiting

  • CU John C. Hobbins Perinatal Center

    Denver, Colorado 80202
    United States

    Active - Recruiting

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