Royal Jelly as a Strategy to Modulate Inflammation and Oxidative Stress in Patients With Systemic Arterial Hypertension

Last updated: April 1, 2025
Sponsor: Universidade Federal Fluminense
Overall Status: Active - Recruiting

Phase

N/A

Condition

Inflammation

Vascular Diseases

Williams Syndrome

Treatment

Placebo

Royal Jelly

Clinical Study ID

NCT06917131
Denise Mafra21
  • Ages 18-75
  • All Genders

Study Summary

The study aims to evaluate the effect of the royal jelly on inflammation and oxidative stress in participants with systemic arterial hypertension. A longitudinal double-blind randomized clinical trial will be carried out, involving hypertensive participants for two months.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patients using one to three antihypertensive medications, undergoing regularfollow-up at the HUAP Medical Clinic for more than 6 months and without the need forchanges in medication doses in the last 3 months.

Exclusion

Exclusion Criteria:

  • Patients with autoimmune and infectious diseases, diabetes, chronic kidney disease,liver disease, cancer and AIDS will be excluded; pregnant women; those usingcatabolic drugs or antibiotics; use of antioxidant vitamin supplements, prebiotics,probiotics, symbiotics, habitual intake of royal jelly, and who are allergic tocornstarch or report having an allergy to bee stings will also be excluded. Patientswith acute myocardial infarction (AMI) and/or stroke (CVA) in the last 6 months willalso be excluded; with HAS stages 2 or 3.

Study Design

Total Participants: 34
Treatment Group(s): 2
Primary Treatment: Placebo
Phase:
Study Start date:
September 18, 2024
Estimated Completion Date:
December 20, 2025

Study Description

Royal jelly (RG) is considered a superfood that has been used in traditional medicine and dietary supplementation due to its antioxidant, anti-inflammatory, immunomodulatory, and regenerative properties. The antioxidant and anti-inflammatory effects of GR highlight its potential as a natural supplement for the prevention and management of several health conditions. Although in vitro and animal model data are promising, clinical studies are still needed to validate the effects of royal jelly in human populations.

Connect with a study center

  • Denise Mafra

    Rio de janeiro, 22260050
    Brazil

    Active - Recruiting

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