BBO-11818 in Adult Subjects With KRAS Mutant Cancer

Last updated: May 29, 2026
Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
Overall Status: Active - Recruiting

Phase

1

Condition

Neoplasm Metastasis

Non-small Cell Lung Cancer

Adenocarcinoma

Treatment

Platinum chemotherapy (cisplatin or carboplatin)

Nab-paclitaxel

BBO-10203

Clinical Study ID

NCT06917079
TBBO11818-101
KONQUER-101
  • Ages > 18
  • All Genders

Study Summary

A first in human study to evaluate the safety and preliminary antitumor activity of BBO-11818, a pan-KRAS inhibitor, in subjects with locally advanced unresectable or metastatic KRAS mutant solid tumors.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Histologically documented locally advanced and unresectable or metastatic NSCLC,PDAC, CRC, or other solid tumor with KRAS G12A, G12C, G12D, G12S, or G12V mutation

  • Measurable disease by RECIST v1.1

  • Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1

  • Life expectancy >24 weeks

  • Adequate organ function

Exclusion

Exclusion Criteria:

  • Malignancy within the last 2 years as specified in the protocol

  • Untreated brain metastases

Other inclusion/exclusion criteria are specified in the protocol.

Study Design

Total Participants: 665
Treatment Group(s): 12
Primary Treatment: Platinum chemotherapy (cisplatin or carboplatin)
Phase: 1
Study Start date:
March 31, 2025
Estimated Completion Date:
September 30, 2029

Study Description

This is an open-label, multi-center, Phase 1 study designed to evaluate the safety, tolerability, pharmacokinetics, and efficacy of BBO-11818, a pan-KRAS inhibitor, alone and in combination with pembrolizumab, pembrolizumab + cis/carboplatin + pemetrexed, cetuximab, cetuximab + mFOLFOX6, BBO-10203 + mFOLFOX6, BBO-10203 +cetuximab, mFOLFIRINOX, gemcitabine + nab-paclitaxel, or BBO-10203 in subjects with locally advanced unresectable or metastatic KRAS mutant solid tumors. The study includes a dose escalation phase and a dose expansion phase.

Connect with a study center

  • Peter MacCallum Cancer Centre

    Melbourne, Victoria 3000
    Australia

    Active - Recruiting

  • The Angeles Clinic and Research Institute - West Los Angeles Office

    Los Angeles, California 90025
    United States

    Active - Recruiting

  • University of California Davis

    Sacramento, California 95817
    United States

    Active - Recruiting

  • University of California San Diego Moores Cancer Center

    San Diego, California 92037
    United States

    Active - Recruiting

  • University of California San Francisco Helen Diller Family Comprehensive Cancer Center

    San Francisco, California 94158
    United States

    Active - Recruiting

  • Yale University

    New Haven, Connecticut 06510
    United States

    Active - Recruiting

  • Moffitt Cancer Center

    Tampa, Florida 33612
    United States

    Active - Recruiting

  • OSF Healthcare Cancer Institute

    Peoria, Illinois 61637
    United States

    Active - Recruiting

  • Massachusetts General Hospital

    Boston, Massachusetts 02114
    United States

    Active - Recruiting

  • Columbia University Irving Medical Center

    New York, New York 10032
    United States

    Active - Recruiting

  • NYU Langone Health

    New York, New York 10016
    United States

    Active - Recruiting

  • Columbia University Irving Medical Center

    New York 5128581, New York 5128638 10032
    United States

    Active - Recruiting

  • Vanderbilt University Medical Center

    Nashville, Tennessee 37232
    United States

    Active - Recruiting

  • Sarah Cannon Research Institute at Mary Crowley

    Dallas, Texas 75230
    United States

    Active - Recruiting

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas 77030
    United States

    Active - Recruiting

  • NEXT Oncology

    San Antonio, Texas 78229
    United States

    Active - Recruiting

  • Huntsman Cancer Institute

    Salt Lake City, Utah 84112
    United States

    Active - Recruiting

  • Fred Hutchinson Cancer Center

    Seattle, Washington 98109
    United States

    Active - Recruiting

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