Flexagon Plus OTOLoc Colon Anastomosis in Patients Undergoing Surgery

Inclusion Criteria:

1. Aged 22 years or older at screening

2. Candidate for surgery requiring Right Hemicolectomy or Sigmoid / Low Anteriorresection (with anastomosis above the peritoneal reflection) with cardiac/medicalclearance for surgery

3. Able to understand and sign informed consent document

4. American Society of Anesthesiologists (ASA) score < IV at time of procedure

5. All cancer patients must have completed chemotherapy ≥2 months prior to procedure

6. Lives, and intends to remain, within a 300 kilometers radius of study center for theduration of the study

7. Able to refrain from smoking during study follow-up period

Exclusion Criteria:

1. Known or suspected allergy to silicone, nickel, titanium or Nitinol

2. BMI > 55 kg/m2

3. Uncontrolled diabetes (defined as HbA1c >10%)

4. Congenital or acquired anomalies of the GI tract, including atresia or malrotationthat would inhibit passing of SFM magnet

5. Diagnosed with obstructed or perforated colon cancer

6. Any documented conditions for which endoscopy and/or laparoscopy would becontraindicated or history of previous technically difficult or failed endoscopythat may suggest difficulty during endoscopic delivery of magnets

7. Any previous major surgery on the stomach, duodenum, hepatobiliary tree, pancreas,Whipple or right colon

8. History of recurrent small bowel obstructions.

9. Coagulation deficiency not normalized by medical treatment or platelet count <50,000/µL

10. Known moderate to severe renal disease (eGFR < 44 milliliters per minute per 1.73m2)or ongoing dialysis

11. Hyperkalemia / hypercoagulability or prior Venus Thromboembolism / PulmonaryEmbolism

12. Immunocompromised (e.g., active treatment for malignancies, hematologic malignancy,on immunosuppressive therapy, moderate or severe primary immunodeficiency, advancedor untreated HIV, active treatment with high-dose corticosteroids (i.e., 20 or moremg of prednisone or equivalent per day when administered for 2 or more weeks priorto surgery) or other immunosuppressive or immunomodulatory agents

13. Congestive heart failure with ejection fraction <35% or clinically significantarrhythmia (any rhythm disturbances except sinus tachycardia, sinus bradycardia or asinus rhythm with premature atrial or ventricular complexes)

14. Decompensated chronic obstructive lung disease

15. Active or suspected infection at the surgical site or a CDC Class 3/contaminated orClass 4/dirty-infected surgical wound.

16. Contraindication to general anesthesia

17. Breast-feeding, pregnant, or planning on becoming pregnant during the follow-upperiod

18. Currently participating or has participated in another clinical trial within thepast 30 days and is receiving/has received an investigational drug, device, orbiologic agent

19. Contraindication to general anesthesia

20. Participant is not appropriate for inclusion in the clinical trial, per the medicalopinion of the Principal Investigator