Phase
Condition
Depression
Treatment
Bright light therapy（High light intensity）
Bright light therapy（Low light intensity）
Dim red light placebo-controlled intervention
Clinical Study ID
Study Summary
Eligibility Criteria
Inclusion
- Adolescents with Major Depressive Disorder Inclusion Criteria:all of the following conditions were met for inclusion:
- Meet the diagnostic criteria for depressive episodes in the Diagnostic andStatistical Manual of Mental Disorders (DSM-V) (either first or recurrent), andbe clearly diagnosed by two physicians using MINI-kid 2.0;
- Age 13 to 17 years, right-handed, and gender-neutral; ③Not currently onmedication; or have been stabilized on the original medication regimen forat least 1 week; ④ Hamilton Depression Scale (HAMD-17) score ≥14 atbaseline; ⑤ Years of education ≥ 5 years and can cooperate in completingthe scale assessment;
- Subjects volunteered to participate in the study, and both subjectsand guardians signed an informed consent form.
Exclusion
Exclusion Criteria: excluded if any of the following conditions are met:
- A history of previous or current episodes of other psychiatric disorders, suchas (schizophrenia, autism spectrum disorders, and schizoaffective disorders,etc.);
- Previous history of drug or substance abuse or dependence;
- Total score of ≥ 8 on the Young's Mania Scale as assessed by theinvestigator for the subject; ④ Have received, or are currently receiving, or have planned toreceive in the last month, other systemic interventions other thanmedication in the 6 months prior to enrollment, e.g., systemicpsychotherapy (1 to 2 times per month for more than 6 months),physical therapy other than phototherapy, or exercise therapy; ⑤ Those who are medically unstable, or unable to cooperate incompleting the study; those who are currently at serious risk ofsuicide as assessed by the investigator (HAMD-17 entry 3 score ≥ 3);
- Comorbid serious physical illnesses such as severe liverfunction abnormalities, hyper/hypothyroidism and abnormalthyroid function, encephalitis, head trauma or coma, epilepsy,loss of consciousness, diabetes mellitus, renal failure, etc.;or those whose clinical laboratory findings at the time ofenrollment are, in the opinion of the investigator,significantly out of the reference range and of clinicalsignificance; ⑦ Comorbid visual pathway diseases (retinaldetachment, optic nerve atrophy, macular degeneration, etc.),systemic diseases that have an impact on the retina, high myopia (myopia of 600 degrees and above); or those who are usingphotosensitizers, drugs with potential photosensitizing effects (e.g., chlorpromazine, tricyclic antidepressant, chrysothema,etc.); ⑧ According to the opinion of the research group, thosewho are not suitable for other conditions of this study.
- Adolescent Health Controls Criteria for inclusion: All of the following conditions were met for inclusion:
- Age 13-17 years old, right-handed, gender is not limited;
- Years of education ≥ 5 years, can cooperate with the completion of thescale assessment; ③Subjects volunteered to participate in the study, andboth subjects and guardians signed an informed consent form. Exclusion Criteria: excluded if any of the following conditions are met:
①Previous or current suffering from any mental illness (e.g., schizophrenia,loneliness spectrum disorders, anxiety disorders and schizoaffective disorders,etc.), or a history of drug or substance abuse or dependence;
② First-degree relatives with a family history of mental illness;
③Comorbid serious physical illnesses such as severe liver function abnormalities,hyper/hypothyroidism and thyroid function abnormalities, encephalitis, head traumaor coma, epilepsy, loss of consciousness, diabetes mellitus, renal failure, etc.; orthose whose clinical laboratory findings at the time of enrollment were consideredby the investigator to be significantly out of the reference range and of clinicalsignificance;
④ Those with other conditions that, according to the opinion of the study group, arenot suitable for this study.