Pediatric Neuroimaging

• INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

• Stated willingness to comply with all study procedures and availability for theduration of the study.

• Male or female, 9 to 14 years of age.

• In good general health

• Ability of parent/guardian to understand and the willingness to sign a writteninformed consent document.

• Ability of participant to participate in the assent process and willingness to signa written informed assent document.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

• Any known brain abnormalities (e.g. tumor, periventricular leukomalacia,microcephaly) or history of medical conditions known to affect cerebral micro ormacro-structural integrity (e.g., epilepsy, history of stroke, head injury with aloss of consciousness of one hour or more).

• History neurodevelopmental delay or disorder, learning disability, intellectualdisability (formerly referred to as mental retardation), autism spectrum disorders,and attention18 deficit/hyperactivity disorder (ADHD)), as evaluated history,physical and by the KSADSCOMP).

• History of psychiatric disorder as evaluated by the KSADS-COMP.

• History of prematurity (< 32 weeks gestational age).

• History of endocrine abnormalities, including diagnosed disorders of thyroid,growth, and precocious or delayed puberty

• History of major medical conditions or chronic medical conditions. Examples includeneurological disorders, medical or genetic conditions with associated neurologicalmanifestations, malnutrition, conditions raising risk of micronutrient ormacronutrient deficiencies (e.g. inflammatory bowel disease), untreated chronicanemia, cardiovascular disease, significant lung disease (e.g. bronchiectasis),significant liver disease, significant kidney disease, significant autoimmunecondition, and chronic infections (e.g. HIV, hepatitis B).

• Pregnancy.

• Not eligible to have an MRI as per the MRI eligibility form and the safety standardsof the NIA 3T MRI center.

• Presence of hardware (e.g. orthodontic braces) that may interfere with MRI dataquality.

• Any other condition which in the investigator s opinion may adversely affect thesubject s ability to complete the study or its measures or which may posesignificant risk to the subject.